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姓 名:
施剑林
性    别:
专家类别:
杰青;百人;研究员;百千万人才
学 历:
博士研究生
电 话:
021-52412712
传 真:
021-52413122
电子邮件:
jlshi@mail.sic.ac.cn
个人主页:
http://www.skl.sic.cas.cn/yjly/swyy/sjl
邮政编码:
200050
通讯地址:
上海市定西路1295号

简历:

  施剑林,男,中国科学院上海硅酸盐研究所研究员,博士生导师,曾任上海硅酸盐研究所所长,高性能陶瓷与超微结构国家重点实验室主任。1983年毕业于南京工业大学,1989年于上海硅酸盐研究所获博士学位。中科院首批“百人计划”入选者(1994),国家杰出青年基金获得者(1996),教育部长江学者特聘教授(2008)。担任国家重大基础研究计划“信息功能陶瓷若干基础问题研究”(2002-2008)和国家重点纳米专项“半封闭空间机动车排放污染物治理的关键纳米技术” (2013--)首席科学家,同时还承担并负责多项国家自然科学重点基金、“863”材料高技术和科学院创新方向性等多项国家与地方科研项目。

  曾从事先进陶瓷材料制备科学,烧结理论,结构陶瓷高温可靠性评价透明陶瓷等研究(1983-2005),现主要从事无机纳米材料,介孔材料与介孔主客体复合材料的合成、非均相催化性能,介孔纳米颗粒的可控合成及其生物相容性、多功能化、药物输运和纳米诊疗剂等方面的研究(1989至今)。

  发表杂志SCI论文380余篇,他人引用13000余次,H-index为62。出版专著《现代无机非金属材料工艺学》、 《先进陶瓷物理化学原理与技术》、 《无机光学透明材料--透明陶瓷》三本。 以第一完成人获国家自然科学二等奖一项(2011年度)、上海市自然科学一等奖两项(2008年,2014年)和上海市科技进步一等奖(2009年)一项等科技奖励。 另获两院院士评选中国十大科技进展(2005年)、中国青年科技奖、中国青年化学奖、中科院青年科学家奖、上海市自然科学牡丹奖、上海市科技精英等奖励。

  教育经历:

  1983年毕业于南京工业大学,1989年于上海硅酸盐研究所获博士学位。 

  工作经历:

  1989~1992,中国科学院上海硅酸盐研究所,助理研究员; 

  1993~1994,德国斯图加特马普金属所,访问学者; 

  1994~至今,中国科学院上海硅酸盐研究所,研究员。 

  曾任中国科学院上海硅酸盐研究所所长,高性能陶瓷与超微结构国家重点实验室主任。 

  获奖及荣誉:

获奖项目名称 

获奖时间 

奖项名称 

奖励等级 

授奖部门(单位) 

介孔剂复合材料设计合成、非均相催化性能与应用探索 

2011-12-23 

国家自然科学奖 

二等 

国务院 

空心介孔氧化硅纳米颗粒的制备、药物缓控释和磁功能化 

2014-12-31 

上海市自然科学奖 

一等 

上海市人民政府 

介孔主客体复合材料组装方法与催化性能研究 

2008-12-31 

上海市自然科学奖 

一等 

上海市人民政府 

低比表面积高烧结活性氧化锆粉体与制品关键技术开发与产业化 

2009-12-31 

上海市科学技术奖 

一等 

上海市人民政府 

先进陶瓷固相烧结:理论与实际 

2006-11-24 

上海市科学技术奖 

二等 

上海市人民政府 

先进陶瓷固相烧结理论与相关问题研究中 

2006-12-31 

中国材料研究学会科学技术奖 

二等 

国材料研究学会 

纳米氧化硅粉体制备科学与团聚问题研究 

1998-12 

中国科学院自然科学奖 

二等 

中国科学院 

  代表性论著:

  A)介孔与介孔复合材料合成与催化

  1. Lianzhou Wang, Jianlin Shi*, Wenhua Zhang, Meiling Ruan, Jian Yu, and Dongsheng Yan, “Self-Organization of Ordered Silver Nanocrystal Arrays on Cubic Mesoporous Silica Surfaces”,Chemistry of Materials, 11(11) (1999), 3015-3017.
  2. Wenhua Zhang, Jianlin Shi*, Lianzhou Wang, and Dongsheng Yan, “Preparation and Characterization of ZnO Clusters inside Mesoporous Silica”, Chemistry of Materials, 12(5) (2000), 1408-1413.
  3. Hangrong Chen, Jianlin Shi*, Weimin Huang, Meiling Ruan, Dongsheng Yan, “Incorporation into the Inorganic Wall of Ordered Porous Zirconium Oxide via Direct Synthesis”, Chemistry of Materials, 13(5) (2001), 1035-1040.
  4. ZiLe Hua, Jianlin Shi*, Ling-Xia Zhang, Mei-Ling Ruan and Jina Yan, “Formation of Nano-sied TiO2 in Mesoporous Silica Thin Film”, Advanced Materials, 14(11) (2002), 830-833.
  5. Lingxia Zhang, Jianlin Shi*, Jian Yu, Zile Hua, Xueguo Zhao, Meiling Ruan, “A New In-situ Reduction Route for the Synthesis of Pt Nanoclusters in the Pore Channels of SBA-15 Mesoporous Materials”, Advanced Materials, 14(20) (2002), 1510-1513.
  6. Hangrong Chen, Jianlin Shi*, Jina Yan, Zile Hua, Hongguang Chen and Dongsheng Yan, “A New Method for the Synthesis of Highly Dispersive and Catalytically Active Platinum Nanoparticles Confined in Mesoporous Zirconia” Advanced Materials, 15(13) (2003), 1078-1081.
  7. Liang Li, Jianlin Shi* Linxia Zhang, Liangming Xiong, and Jina Yan, “A Novel and Simple in-stiu Reduction Route for The Synthesis of Ultra-Thin Metal Nano-Coating in the Channels of Mesoporous Silica Materials”, Advanced Materials, 16(3)(2004), 1079-1082.
  8. Liangming Xiong, Jianlin Shi*, Jinlou Gu, Weihua Shen, Xiaoping Dong, Hangrong Chen, Lingxia Zhang, Jianhua Gao and Meiling Ruan, “Directed Growth of Well-Aligned Zinc Silicate Nanowires Along the Channels of Surfactant-Assembled Mesoporous Silica”, Small,1(11) (2005),1044-1047.
  9. Jinlou Gu, Jianlin Shi*, Guanjun You, Liangming Xiong, Shixiong Qian, Zile Hua, and Hangrong Chen, “A Facile Strategy to Incorporate Highly Dispersed Gold Nanoparticles into the Pore Channels of Mesiporous Silica Thin Films and Its Ultrafast Nonlinear Optical Response,” Advanced Materials,17(5) (2005), 557-560.
  10. Wenru Zhao, Jinlou Gu, Lingxia Zhang, Hangrong Chen, and Jianlin Shi*, “Fabrication of Uniform Magnetic Nanocomposite Spheres with a Magnetic Core/Mesoporous Shell Structure”, Journal of American Chemical Society, 127(25) (2005), 8916-8917.
  11. Xiaoping Dong, Weihua Shen, Yufang Zhu, Liangmin xiong, and Jianlin Shi*, “Facile Synthesis of Manganese-loaded Mesoporous Silica Materials by Direct Reaction Between KMnO4 and an In-Situ Surfactant Template”, Advanced Functional Materials, 15(6) (2005),955-960
  12. Hangrong Chen, Jinlou Gu, Jianlin Shi*,Zhicheng Liu, Jianhua Gao, Meiling Ruan and Dongsheng Yan, “A Composite Surfactant Route for the Synthesis of Thermally Stable and Hierarchically Porous Zirconia with Nano-crystallized Framework”, Advanced Materials, 17(16) (2005), 2010-2014.
  13. Xiaoping Dong, Hangrong Chen, Wenru Zhao, Xia Li, and Jianlin Shi*“Synthesis and Magnetic Properties of Mesostructured γ-Fe2O3/Carbon Composites by a Co-casting Method”, Chemistry of Materials, 19(14) (2007), 3484-3490.
  14. Chichao Yu, Lingxia Zhang, Jianlin Shi*, Jinjin Zhao, Jianhua Gao, and Dongsheng Yan, “A Simple Template-Free Strategy to Synthesize Nanoporous Manganese and Nickel Oxides with Narrow Pore Size Distribution, and Their Electrochemical Properties,” Advanced Functional Materials, 18(10) (2008), 1544-1554.
  15. Liang Li*, Yingjun Feng, Yongsheng Li, Wenru Zhao, and Jianlin Shi*, “Fe3O4 Core/Layered Double Hydroxide Shell Nanocomposite: Versatile Magnetic Matrix for Anionic Functional Materials”, Angewandte Chemie-International Edition, 48(32) (2009), 5888-5892.
  16. Jian Zhou, Zile Hua, Zhicheng Liu, Wei Wu, Yan Zhu, and Jianlin Shi*,“Direct Synthetic Strategy of Mesoporous ZSM-5 zeolites by Using Conventional Block Copolymer Templates and Improved Catalytic Properties”, ACS Catalysis, 1(4)(2011), 287-291.
  17. )Jianlin Shi*, “On the Synergetic Catalytic Effect in Heterogeneous NanocompositeCatalysts,”Chemical Reviews, 113 (3) (2013), 2139–2181.
  18. Xiangzhi Cui, Lisong Chen, Yongxia Wang, Hangrong Chen, Wenru Zhao, Yongsheng Li, and Jianlin Shi*, “Fabrication of Hierarchically Porous RuO2−CuO/Al−ZrO2 Compositeas Highly Efficient Catalyst for Ammonia-Selective CatalyticOxidation,” ACS Catalysis, 4(7)(2014), 2195-2206.
  19. Xiangzhi Cui, Jianlin Shi*, Yongxia Wang, Yu Chen, Lingxia Zhang, and Zile Hua, “Mesostructured Platinum-Free Anode and Carbon-Free Cathode Catalysts for Durable Proton Exchange Membrane Fuel Cells”, ChemSusChem, 7(1) (2014), 135-145.
  20. Xiangzhi Cui, Yan Zhu, Zile Hua, Jingwei Feng, Ziwei Liu, Lisong Chen and Jianlin Shi*SnO2 nanocrystal-decorated mesoporous ZSM-5 as a precious metal-free electrode catalyst for methanol oxidation. Energy Environ. Sci., 8 (2015), 1261-1266.
  21. Yanyan Du, Zile Hua, Weimin Huang, Meiying Wu, Min Wang, Jin Wang,Xiangzhi Cui, Lingxia Zhang, Hangrong Chen, Jianlin Shi*, Mesostructured amorphous manganese oxides: facile synthesis and highly durable elimination of low-concentration NO at room temperature in air, Chemical Communications, 2015, 51(27), 5887-5889 
  22. Xiangqian Fan, Zheng Xing, Zhu Shu, Lingxia Zhang, Lianzhou Wang, and Jianlin Shi Construction of Graphitic C3N4Based Intramolecular Donor−Acceptor Conjugated Copolymers for Photocatalytic Hydrogen Evolution, ACS Catalysis, 2015, 5, 5008-5015 
  23. Xiaoxia Zhou, Hangrong Chen,* Guobin Zhang, Jin Wang, Zhiguo Xie, Zile Hua,Lingxia Zhang and Jianlin Shi*, Cu/Mn co-loaded hierarchically porous zeolite beta: a highly efficient synergetic catalyst for soot oxidation, Journal of Materials Chemistry A, 2015, 3, 9745-9753  

  (B) 介孔纳米颗粒合成与生物应用  

  1. Yongsheng Li, Jianlin Shi*, Zile Hua, Hangrong Chen, Meiling Ruan and Dongsheng Yan, “Hollow Spheres of Mesoporous Aluminosilicate with a Three Dimensional Pore Network and Extraordinary Hydrothermally Stability”, Nano Letters, 3(5) (2003), 609-612.

  2. Yufang Zhu, Jianlin Shi,* Weihua Shen, Xiaoping Dong, Jingwei Feng, Meilin Ruan, and Yongsheng Li, “Stimuli-Responsive Controlled Drug Release from a Hollow Mesoporous Silica Sphere/Polyelectrolyte Multilayer Core-Shell Structure”, Angewande Chemie-International Edition, 117(32) (2005), 5213- 5217.

  3. Xia Li, Xiupeng Wang, Hangrong Chen, Peng Jiang, Xiaoping Dong, and Jianlin Shi*, “Hierarchically Porous Bioactive Glass Scaffolds Synthesized with a PUF and P123 Co-templated Approach”. Chemistry of Materials, 19(17) (2007): 4322- 4326.

  4. Wenru Zhao, Hangrong Chen, Yongsheng Li, Linag Li, Meidong Lang, and Jianlin Shi*, “Uniform Rattle-Type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and Their Sustained-Release Property”, Advanced Functional Materials,18(18) (2008), 2780-2788.

  5. Qianjun He, Zhiwen Zhang, Yu Gao, Jianlin Shi* and Yaping Li*, “Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano-/Micro- Particles,” Small, 5(23) (2009), 2722-2729.

  6. Qianjun He, Jiamin Zhang, Feng Chen, Limin Guo, Ziyan Zhu, and Jianlin Shi*, “An Anticancer Drug Delivery System Based on Surfactant-templated Mesoporous Silica Nanoparticles,” Biomaterials, 31(30) (2010), 3335-7796.

  7. Qianjun He, Jiamin Zhang, Jianlin Shi*, Ziyan Zhu, Lingxia Zhang, Wenbo Bu, Limin Guo and Yu Chen, “The Effect of PEGylation of Mesoporous Silica Nanoparticles on Nonspecific Binding of Serum Proteins and Cellular Responses”, Biomaterials,31(6) (2010), 1085-1092.

  8. Yu Chen, Hangrong Chen*, Limin Guo, Qianjun He, Feng Chen, Jian Zhou, Jingwei Fei, and Jianlin Shi*, “Hollow/Rattle-Type Mesoporous Nanostructures by a Structural Difference-Based Selective Etching Strategy,” ACS Nano,4(1) (2010), 529-539.

  9. Qianjun He, Jiamin Zhang, Feng Chen, Limin Guo, Ziyan Zhu, and Jianlin Shi*, “An Anti-ROS/Hepatic Fibrosis Drug Delivery System Based on Salvianolic Acid B Loaded Mesoporous Silica Nanoparticles”, Biomaterials,31(30) (2010), 7785-7796.

  10. Yu Chen, Hangrong Chen*, Deping Zeng, Yunbo Tian, Feng Chen, Jingwei Feng, and Jianlin Shi*, “Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery,” ACS Nano,4(10) (2010), 6001-6013.

  11. Dechao Niu, Zhi Ma, Yongsheng Li*, and Jianlin Shi*, “Synthesis of Core-Shell Structured Dual-Mesoporous Silica Spheres with Tunable Pore Size and Controllable Shell Thickness”, Journal of the American Chemical Society, 132(43) (2010), 15144-15147.

  12. Qianjun He, Yu Gao, Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li*, and Jianlin Shi*, “A pH-Responsive Mesoporous Silica Nanoparticles-Based Multi-drug Delivery System for Overcoming Multi-Drug Resistance,” Biomaterials, 32(30) (2011), 7711-7720.

  13. Qianjun He, Zhiwen Zhang, Fang Gao, Yaping Li*, and Jianlin Shi*, “In Vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation”, Small, 7(2) (2011), 271–280

  14. Yu Chen, Hangrong Chen*, Shengjian Zhang, Feng Chen, Lingxia Zhang, Jiamin Zhang, Min Zhu, Huixia Wu, Limin Guo, Jingwei Feng, and Jianlin Shi*, “Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs”, Advanced Functional Materials, 21(2) (2011), 270-278.

  15. Yu Chen, Chen Chu, Yuchuan Zhou, Yanfei Ru, Hangrong Chen*, Feng Chen, Qianjun He, Yonglian Zhang, Linlin Zhang, and Jianlin Shi*, “Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting”, Small, 7(20) (2011), 2935-2944.

  16. Yu Chen, Hangrong Chen*, Yang Sun, Yuanyi Zheng, Deping Zeng, Faqi Li, Shengjian Zhang, Xia Wang, Kun Zhang, Ming Ma, Qianjun He, Linlin Zhang, and Jianlin Shi*, “Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery”, Angewandte Chemie- International Edition, 50(52) (2011), 12505- 12509.

  17. Yu Gao, Yu Chen, Xiufeng Ji, Xinyu He, Qi Yin, Zhiwen Zhang, Jianlin Shi*, and Yaping Li*, “Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles”, ACS Nano, 5(12) (2011), 9788-9798.

  18. Min Zhu, Huixue Wang, Jiyong Liu, Hailong He, Xuguo Hua, Qianjun He, Lingxia Zhang, Xiaojian Ye, and Jianlin Shi*, “A Mesoporous Silica Nanoparticulate/ Beta-TCP/BG Composite Drug Delivery System for Osteoarticular Tuberculosis Therapy”, Biomaterials. 32(7) (2011), 1986-1995.

  19. Huixia Wu, Shengjian Zhang, Jiamin Zhang, Gang Liu, Jianlin Shi*, Lingxia Zhang, Xiangzhi Cuil, Meiling Ruan, Qianjun He, and Wenbo Bu, “A Hollow-Core, Magnetic, and Mesoporous Double-Shell Nanostructure: In Situ Decomposition/Reduction Synthesis, Bioimaging, and Drug-Delivery Properties”, Advanced Functional Materials, 21(10) (2011), 1850–1862.

  20. Limin Pan, Qianjun He, Jianan, Liu, Yu Chen, Ming Ma, Linlin Zhang, and Jianlin Shi*, “Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles,” Journal of American Chemical Society, 134(13) (2012), 5722-5725.

  21. Xia Wang, Hangrong Chen*, Yu, Chen, Ming Ma, Kun Zhang, Faqi Li, Yuanyi, Zheng, Deping Zeng, Qi Wang, and Jianlin Shi*, “Perfluorohexane- Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)”, Advanced Materials, 24(6) (2012), 785-791.

  22. Yu Chen, Hangrong Chen*, Shengjian Zhang, Feng Chen, Shikuan Sun, Qianjun He, Ming Ma, Xia Wang, Huixia Wu, Lingxia Zhang, Linlin Zhang, and Jianlin Shi*, “Structure-Property Relationships in Manganese Oxide-Mesoporous Silica Nanoparticles Used for T1-Weighted MRI and Simultaneous Anti-Cancer Drug Delivery,” Biomaterials, 33(7) (2012), 2388-2398.

  23. Yu Chen, Qi Yin, Xiufeng Ji, Shengjian Zhang, Hangrong Chen*, Yuanyi Zheng, Yang Sun, Haiyun Qu, Zheng Wang, Yaping Li*, Xia Wang, Kun Zhang, Linlin Zhang, and Jianlin Shi*, “Manganese Oxide-Based Multifunctionalized Mesoporous Silica Nanoparticles for pH-responsive MRI, Ultrasonography and Circumvention of MDR in Cancer Cells,” Biomaterials, 33(29) (2012), 7126- 7137.

  24. Yu Chen, Yu Gao, Hangrong Chen*, Deping Zeng, Yaping Li*, Yuanyi Zeng, Faqi Li, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang, and Jianlin Shi*, “Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents”, Advanced Functional Materials, 22(8) (2012), 1586-1597.

  25. Qianjun He, Ming Ma, Chenyang Wei, and Jianlin Shi*, “Mesoporous Carbon@Silicon-Silica Nanotheranostics for Snchronous Delivery of Insoluble Drugs and Luminescence Imaging”, Biomaterials, 33(17) (2012), 4392-4402.

  26. Ming Ma, Hangrong Chen*, Yu Chen, Xia Wang, Feng, Chen, Xiangzhi Cui, and Jianlin Shi*, “Au-Capped Magnetic Core/Mesoporous Silica Shell Nanoparticles for Combined Photothermo-/Chemo-Therapy and Multimodal Imaging”, Biomaterials, 33(3) (2012), 989-998.

  27. Yu Chen, Pengfei Xu, Hangrong Chen*,Yongsheng Li, Wenbo Bu, Zhu Shu, Yaping Li*, jiamin Zhang, Lingxia Zhang, Limin Pan, Xiangzhi Cui, Zile Hua, Jin Wang, Linlin Zhang, and Jianlin Shi*, “Colloidal HPMO Nanoparticles: Silica-Etching Chemistry Tailoring, Topological Transformation, and Nano-Biomedical Applications”, Advanced Materials, 25(22) (2013), 3100-3105.

  28. Yu Chen, Hangrong Chen*, and Jianlin Shi*, “In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles”, Advanced Materials, 25(23) (2013), 3144-3176.

  29. Dechao Niu, Xia Wang; Yongsheng Li*,Yuanyi Zheng, Faqi Li, Hangrong Chen, Jinlou Gu, Wenru Zhao, and Jianlin Shi*, “Facile Synthesis of Magnetite/Perfluorocarbon Co-Loaded Organic/Inorganic Hybrid Vesicles for Dual-Modality Ultrasound/Magnetic Resonance Imaging and Imaging-Guided High-Intensity Focused Ultrasound Ablation”, Advanced Materials, 25(19) (2013), 2686-2692.

  30. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, and Jianlin Shi*, “Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging”, Journal of the American Chemical Society, 135(17) (2013), 6494-6503.

  31. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, and Jianlin Shi*, “A Core/Satellite Multifunctional Nanotheranostic for In Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy”, Journal of the American Chemical Society, 135(35) (2013), 13041- 13048.

  32. Limin Pan, Jianan Liu, Qianjun He, Lijun Wang, and Jianlin Shi*, “Overcoming Multidrug Resistance of Cancer Cells by Direct Intranuclear Drug Delivery Using TAT-Conjugated Mesoporous Silica Nanoparticles”, Biomaterials, 34(11) (2013), 2719-2730.

  33. Jianan Liu, Wenbo Bu*, Limin Pan, and Jianlin Shi,* “NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica”, Angewandte Chemie-International Edition, 52(16) (2013), 4375-4379.

  34. Xia Wang, Hangrong Chen*, Yuanyi Zheng, Ming Ma, Yu Chen, Kun Zhang, Deping Zeng, and Jianlin Shi*, “Au-NanoparticleCoated Mesoporous Silica Nanocapsule-Based MultifunctionalPlatform for Ultrasound Mediated Imaging, Cytoclasis and Tumor Ablation”, Biomaterials, 34(8) (2013), 2057-2068.

  35. Yu Chen, Hangrong Chen* and Jianlin Shi*, “Construction of Homogenous/ Heterogeneous Hollow Mesoporous Silica Nanostructures by Silica-Etching Chemistry: Principles, Synthesis, and Applications”, Accounts of Chemical Research, 47(1) (2014), 125-137.

  36. Yu Chen, Pengfei Xu, Meiying Wu, Qingshuo Meng, Hangrong Chen*, Zhu Shu, Jin Wang, Lingxia Zhang, Yaping Li* and Jianlin Shi*, “Colloidal RBC-Shaped, Hydrophilic, and Hollow Mesoporous Carbon Nanocapsules for Highly Efficient Biomedical Engineering”, Advanced Materials, 26(25) (2014), 4294-4301.

  37. Yu Chen, Pengfei Xu, Zhu Shu, Meiying Wu, Lianzhou Wang, Shengjian Zhang, Yuanyi Zheng, Hangrong Chen*, Jin Wang, Yaping Li* and Jianlin Shi*, “Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics,” Advanced Functional Materials, 24(28) (2014), 4386-4396.

  38. Yu Chen, Qingshuo Meng, Meiying Wu, Shige Wang, Pengfei Xu, Hangrong Chen, Yaping Li*, Lingxia Zhang, Lianzhou Wang* and Jianlin Shi*, “Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework- Hybridization Approach for Biomedicine”, Journal of the American Chemical Society, 136(46) (2014), 16326-16334.

  39. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Qianjun He, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Dalong Ni, Jianan Liu, and Jianlin Shi*, “A Smart Upconversion-Based Mesoporous Silica Nanotheranostic System for Synergetic Chemo-/Radio-/Photodynamic Therapy and Simultaneous MR/UCL Imaging”, Biomaterials, 35(32) (2014), 8992-9002.

  40. Xiaoyu Li, Qianjun He, and Jianlin Shi*, “Global Gene Expression Analysis of Cellular Death Mechanisms Induced by Mesoporous Silica Nanoparticle-Based Drug Delivery System”, ACS Nano, 8(2) (2014), 1309-1320.

  41. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangping Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, and Jianlin Shi*, “Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging”, Angewandte Chemie-International Edition, 53(18) (2014), 4551-4555.

  42. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, and Jianlin Shi*, “Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation”, Journal of the American Chemical Society, 136(27) (2014), 9701-9709.

  43. Ming Ma, Huixiong Xu, Hangrong Chen*, Xiaoqing Jia, Kun Zhang, Qi Wang, Shuguang Zheng, Rong Wu, Minghua Yao, Xiaojun Cai, Faqi Li, and Jianlin Shi*, “A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound”, Advanced Materials, 26(43) (2014), 7378-7385.

  44. Limin Pan, Jianan Liu, Qianjun He, and Jianlin Shi*, “MSN-Mediated Sequential Vascular-to-Cell Nuclear-Targeted Drug Delivery for Efficient Tumor Regression”, Advanced Materials, 26(39) (2014), 6742-6748.

  45. Limin Pan, Jianan Liu, and Jianlin Shi*, “Intranuclear Photosensitizer Delivery and Photosensitization for Enhanced Photodynamic Therapy with Ultralow Irradiance”, Advanced Functional Materials, 24(46) (2014), 7318–7327.

  46. Meiying Wu, Qingshuo Meng, Yu Chen, Pengfei Xu, Shengjian Zhang, Yaping Li*, Lingxia Zhang, Min Wang, Heliang Yao, and Jianlin Shi*, “Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH-Responsive Theranostic Platform”, Advanced Functional Materials, 24(27) (2014), 4273-4283.

  47. Xia Wang, Hangrong Chen*, Kun Zhang, Ming Ma, Faqi Li, Deping Zeng, Shuguang Zheng, Yu Chen,Lixin Jiang, Huixiong Xu,and Jianlin Shi*, “An Intelligent Nanotheranostic Agent for Targeting, Redox-Responsive Ultrasound Imaging, and Imaging-Guided High-Intensity Focused Ultrasound Synergistic Therapy”, Small,10(7) (2014), 1403-1411.

  48. Qianjun He, and Jianlin Shi*, “MSN anti-cancer nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance and Metastasis Inhibition”, Advanced Materials, 26(3) (2014), 391–411.

  49. Kun Zhang, Hangrong Chen*, Faqi Li, Qi Wang, Shuguang Zheng, Huixiong Xu, Ming Ma, Xiaoqing Jia, Yu Chen, Juan Mou, Xia Wang, and Jianlin Shi*, “A Continuous Tri-phase Transition Effect for HIFU-Mediated Intravenous Drug Delivery”, Biomaterials, 35(22) (2014),5875-5885.

  50. Dechao Niu, Zuojin Liu, Yongsheng Li*, Xiaofeng Luo, Junyong Zhang, Jianping Gong, and Jianlin Shi*, “Monodispersed and Ordered Large-Pore Mesoporous Silica Nanospheres with Tunable Pore Structure for Magnetic Functionalization and Gene Delivery”, Advanced Materials, 26(29) (2014), 4947-4953.

  51. Yongsheng Li*, and Jianlin Shi*, “Hollow-Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications”, Advanced Materials, 26(20) (2014), 3176-3205.

  52. Meiying Wu, Qingshuo Meng, Yu Chen*, Yanyan Du, Lingxia Zhang, Yaping Li*, Linlin Zhang, Jianlin Shi*, “Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery”, Advanced Materials, 27(2)(2015), 215-222.

  53. Xiaoyu Li, Limin Pan,Jianlin Shi*, Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms, Advanced Healthcare Materials, 2015, 4(17), 2641-2648 

  54. Jia-Nan Liu, Wen-Bo Bu,* and Jian-Lin Shi*, Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics, Accounts of Chemical Research, 2015, 48(7), 1797-1805 

  55. Kun Zhang, Hangrong Chen*, Jianlin Shi*, Double-scattering/reflection in a Single Nanoparticle for Intensified Ultrasound Imaging, Scientific Reports, 2015, 5(8766), 1-11  

  56. Kun Zhang, Hangrong Chen*, Xiaoqing Jia, Juan Mou, Jianlin Shi*, CO2 bubbling-based ‘Nanobomb’ System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation, Theranostics, 2015, 5(11), 1291-1302 

  C)非介孔纳米材料合成与性能 

  1. Dechao Niu, Yongsheng Li*, Zhi Ma, Hua Diao, Jinlou Gu, Hangrong Chen, Wenru Zhao, Meiling Ruan, Yonglian Zhang, and Jianlin Shi*, “Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes”, Advanced Functional Materials, 20(5)(2010), 773-780.

  2. Feng Chen,Wenbo Bu*, Shengjian, Zhang, Xiaohang Liu, Jianan Liu, Huaiyong Xing, Qingfeng Xiao, Liangping Zhou, Weijun Peng, Lianzhou Wang, and Jianlin Shi*, “Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes”, Advanced Functional Materials, 21 (22)(2011), 4285-4294.

  3. Wenjie Dong, Yongsheng Li*, Dechao Niu, Zhi Ma, Jinlou Gu, Yi Chen, Wenru Zhao, Xiaohang Liu, Changsheng Liu, and Jianlin Shi*,“Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nano- composite for Bimodal Imaging and Photothermal Therapy”, Advanced Materials, 23(15)(2011), 5392-5397.

  4. Jianan Liu, Wenbo Bu*, Limin Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuaile Zhao, Weijun Peng, and Jianlin Shi*, “Simultaneous Nuclear Imaging and Intranuclear Drug Delivery by Nuclear-targeted Multifunctional Upconversion Nanoprobes,”Biomaterials, 33(29)(2012), 7282-7290.

  5. Qingfeng Xiao, Wenbo Bu*, Qingguo Ren, Shengjian Zhang,Huaiyong Xing, Feng Chen, Ming Li, Xiangpeng Zheng, Yanqing Hua, Liangping Zhou, Weijun Peng, Haiyun Qu, Zheng Wang, Kuaile Zhao, and Jianlin Shi*, “Radiopaque Fluorescence-transparent TaOx Decorated Upconversion Nanophosphors for in vivo CT/MR/UCL Trimodal Imaging,” Biomaterials, 33(30)(2012), 7530-7539.

  6. Huaiyong Xing, Wenbo Bu*, Shengjian Zhang, Xiangpeng Zheng, Ming Li, Feng Chen, Qianjun He, Liangping Zhou, Weijun Peng, Yanqing Hua, and Jianlin Shi*, “Multifunctional Nanoprobes for Upconversion Fluorescence, MR and CT Trimodal Imaging”, Biomaterials, 33(4)(2012), 1079-1089.

  7. Huaiyong Xing, Wenbo Bu*, Qingguo Ren, Xiangpeng Zheng, Ming Li, Shengjian Zhang, Haiyun Qu, Zheng Wang, Yanqing Hua, Kuaile Zhao, Liangping Zhou, Weijun Peng, and Jianlin Shi*, “A NaYbF4: Tm3+ Nanoprobe for CT and NIR-to-NIR Fluorescent Bimodal Imaging,” Biomaterials, 3(21)(2012), 5384-5393.

  8. Feng Chen, Wenbo Bu*, Shengjian Zhang, Jianan Liu, Weipei Fan, Liangping Zhou, Weijun Peng, and Jianlin Shi*, “Gd3+-Ion-Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization”, Advanced Functional Materials, 23(3)( 2013), 298-307.

  9. Lijun Wang, Huaiyong Xing, Shengjian Zhang, Qingguo Ren, Limin Pan, Kun Zhang, Wenbo Bu, Xiangpeng Zheng, Lianping Zhou, Weijun Peng, Yanqing Hua, and Jianlin Shi*, “A Gd-doped Mg-Al-LDH/Au Nanocomposite for CT/MR Bimodal Imagings and Simultaneous Drug Delivery”, Biomaterials, 34(13)(2013), 3390-3401.

  10. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, and Jianlin Shi*,Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging”, Advanced Materials, 26(23)(2014), 3867-3872.

  11. Dalong Ni, Wenbo Bu*, Shengjian Zhang, Xianpeng Zhang, Ming Li, Huaiyong Xing, Qingfeng Xiao, Yanyan Liu, Yanqing Hua, Liangping Zhou, Weijun Peng, Kuaile Zhao, and Jianlin Shi*, “Single Ho3+-Doped Upconversion Nanoparticles for High-Performance T2-Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging”, Advanced Functional Materials, 24(42)(2014), 6613-6620.

  12. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Huaiyong Xing, Fang Han, Qingfeng Xiao, Zhenwei Yao, Feng Chen, Qianjun He, Jianan Liu, Shengjian Zhang, Wenpei Fan, Liangping Zhou, Weijun Peng, and Jianlin Shi*, “Dual-Targeting Upconversion Nanoprobes across the Blood-Brain Barrier for Magnetic Resonance/ Fluorescence Imaging of Intracranial Glioblastoma”, ACS Nano, 8(2)(2014), 1231-1242.

  13. Yu Chen, Delai Ye, Meiying Wu, Hangrong Chen, Linlin Zhang, and Jianlin Shi*, and Lianzhou Wang*, “Break-up of Two-Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer”, Advanced Materials, 26(41)(2014), 7019-7026.

  14. Ming Ma, Yan Huang, Hangrong Chen*, Xiaoqing Jia, Shige Wang, Zizheng Wang, Jianlin Shi*, “Bi2S3-Embedded Mesoporous Silica Nanoparticles for Efficient Drug Delivery and Interstitial Radiotherapy Sensitization”, Biomaterials, 37(2015), 447-455.

  15. Yongping Gao, Yongsheng Li*, Yao Wang, Yi Chen, Jinlou Gu, Wenru Zhao, Jian Ding, Jianlin Shi*, “Controlled Synthesis of Multilayered Gold Nanoshells for Enhanced Photothermal Therapy and SERS Detection”, Small, 11(1)(2015), 77-83.

  16. Shige Wang, Kai Li, Yu Chen, Hangrong Chen, Ming Ma, Jingwei Feng, Qinghua Zhao, Jianlin Shi*, “Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor”, Biomaterials, 39(2015), 206-217.

  17. Wenpei Fan, Bo Shen, Wenbo Bu*, Zhaowen Cui, Kuaile Zhao, Jianlin Shi*, Design of an intelligent sub-50 nm nuclear targeting nanotheranostic system for imaging guided intranuclear radiosensitization, Chemical Science, 2015, 6(3), 1747-1753

  18. Wenpei Fan, Wenbo Bu*, Bo Shen, Zhaowen Cui, Kuaile Zhao, Jianlin Shi*, Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy, Advanced Materials, 2015, 27(28), 4155-4161

  19. Yanyan Liu, Wenbo Bu*, Wenpei Fan, Jianan Liu, Jianlin Shi*, Radiation-/Hypoxia-induced Solid Tumor Metastasis and Regrowth Inhibited by Hypoxia-specific Upconversion Nanotheranostics, Biomaterials, 2015,49,1-8

  20. Yanyan Liu, Wenbo Bu*, Qingfeng Xiao, Wenpei Fan, Jianan Liu, Jianlin Shi*,Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors, Angewandte Chemie International Edition, 2015, 54(28), 8105-8109

  21. Juan Mou, Chengbo Liu, Pei Li, Yu Chen, Hangrong Chen* and Jianlin Shi*, A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imagin, Biomaterials, 2015,,57,12-21

  22. Juan Mou, Pei Li, Chengbo Liu, Huixiong Xu, Yu Chen, Hangrong Chen* and Jianlin Shi*, Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy, Small, 2015, 11(19), 2275-2283

  23. Dalong Ni, Jiawen Zhang,Wenbo Bu, Chen Zhang, Zhenwei Yao, Huaiyong Xing, Jing Wang, Fei Duan, Yanyan Liu, Wenpei Fan, Xiaoyuan Feng, Jianlin Shi*, PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging, Biomaterials, 2016, 76,218-225

  24. Shige Wang, Xiang Li, Yu Chen, Xiaojun Cai, Heliang Yao, Wei Gao, Yuanyi Zheng, Xiao An, Hangrong Chen* and Jianlin Shi, A facile One-pot Synthesis of Two-Dimensional MoS2/Bi2S3 Composite Theranostic Nanosystem for Multi-Modality Tumor Imaging and Therapy, Advanced Materials, 2015, 27(17), 2775-2782

  25. Shige Wang, Yu Chen, Xiang Li, Wei Gao, Linlin Zhang, Jun Liu, Yuanyi Zheng, Hangrong Chen*, Jianlin Shi*, Injectable 2D MoS2-Integrated Drug Delivering Implant for Highly Effi cient NIR-Triggered Synergistic Tumor Hyperthermia, Advanced Materials, 2015, 27(44), 7117-7122

  26. Chen Zhang, Kuaile Zhao, Wenbo Bu,* Dalong Ni, Yanyan Liu, Jingwei Feng, and Jianlin Shi*, Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence, Angewandte Chemie International Edition, 201554(6): 1170-1174

  承担科研项目情况  

  1. 中国科学院“百人计划”,19941997200 
  2. 国家自然科学基金面上基金:微波烧结新型陶瓷材料,1989.1---1991.12,后期负责人,58972097, 5.5 
  3. 国家自然科学基金面上基金:陶瓷超塑性形变的界面行为,1993.1---1995.12,负责人,592820146.0 
  4. 国家自然科学基金面上基金:,复相陶瓷的高温蠕变与疲劳研究,1995.1---1997.1,负责人,594520016.0 
  5. 国家自然科学基金面上基金:复相陶瓷材料高温拉伸蠕变性能研究,1998.1---2000.12,负责人,5977200815  
  6. 国家自然科学基金面上基金:有序介孔材料中的微粒组装及其光电性能探索,1999.1---2001.12,负责人,5988200714  
  7. 上海市启明星计划:复相陶瓷的高温疲劳与蠕变研究,负责人,1994.10---1996.10, 94QEM14085  
  8. 上海市基础研究重点项目: 先进陶瓷材料界面设计,1995.10---1998.10,负责人96JC140840  
  9. 上海市优秀启明星计划(启明星后):复相陶瓷材料的设计与高温可靠性评价,1996.10---1999.10,负责人,97QEM140810  
  10. 国家自然科学基金面上基金:纳米团簇-有序介孔复合材料的制备及催化性能研究,2002.1---2004.12,负责人,50172057, 20  
  11. 上海光科技项目:光通讯连接器氧化锆插芯研制,2001.10---2003.4, 负责人,40万。  
  12. 国家自然科学基金重点基金:异质组装介孔复相材料的研究, 2003.1---2005.12,负责人,50232050 120  
  13. 中科院创新方向性项目:介观层次上低维与块体无机复合材料设计、制备与性能,2002.7---2005.7, 负责人,KGCX2-sw-205290  
  14. 国家高技术新材料领域“863”项目:陶瓷插芯用氧化锆粉体的国产化研究, 902002.1---2004.12, 2001AA33305,负责人 
  15. 国家高技术发展计划(863), 新型结构介孔及其复合材料的制备与催化应用, 2002.9---2005.8 2002AA321010,40万,课题负责人  
  16. 上海市纳米科技项目:“纳米颗粒复合薄膜制备与光学非线性研究”, 负责人,2002.1---2004.12, 50, 0252nm083  
  17. 国家重大基础研究项目:信息功能陶瓷的若干基础问题研究,2003.1---2007.12, 首席科学家之一,2002CB6133002500  
  18. 国家计委高技术产业化示范项目:“光纤连接器用关键陶瓷部件的产业化”,负责人,2003---2005900   
  19. 上海市纳米专项“用于药物释放的高稳定性立方介孔中空球的制备、改性及其应用研究”, 2004.1---2005.1240万元,0352nm101, 负责人
  20. 上海市科学技术委员会技术标准专项:“低比表面积高烧结活性氧化锆粉体”03DZ05049    2003.10---2005.1020万, 负责人 
  21. 上海市科学技术委员会光技术专项:“一体化陶瓷高强度气体放电灯管的制备”,036105020 2003.10---2005.190万,负责人 
  22. 国家基金委杰出青年基金,“先进陶瓷材料制备科学与高温力学性能研究”80万,1997. 1---2000.12, 59625204,负责人  
  23. 上海市科学技术委员会“优秀学科带头人计划”:“铪基陶瓷闪烁体的探索研究“, 03XD14004 2003.12---2005.10, 负责人  
  24. 国家自然科学基金重点基金: “新型介孔主客体复合材料及其非均相催化性能调控”,20633090, 190万,2007.1---2010.12, 负责人  
  25. 上海市纳米专项, “新型纳米靶向控释技术”, 0652nm014, 40万, 2006.9---2008.9. 负责人  
  26. 中科院创新方向性项目:药用纳米材料的设计与制备, KJCX2.YW.M02, 课题三负责人,90万, 2007.1---2009.12 
  27. 中科院创新方向性项目:新型药物可控释放材料, 850万, 2008.5---2011.4 KGCX2-YW-210 首席兼课题一负责人, 330万, 编号:KGCX2-YW-210-03 
  28. 国家自然科学重点基金: 新型无机纳米载体的结构调控即抗癌药物控释与靶向性能研究,290万, 2012.01---2016.1251132009,负责人  
  29. 国家高技术研究发展计划863项目:城市地下空间机动车排放污染净化技术与示范,126万,2012,1---2014,122012AA062703,负责人 
  30. 上海市科委基础研究重点项目:NO室温催化氧化及其在城市隧道污染物治理中的应用研究,35万,2012.1---2014.1211JC1413400,负责人 
  31. 国家重大研究计划:“半封闭空间机动车排放污染物治理的关键纳米技术”, 2600万, 2013---20172013CB93320,首席科学家兼第二课题负责人 

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