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姓 名:
陈航榕
性    别:
专家类别:
研究员;杰青
学 历:
博士研究生
电 话:
021-52412706
传 真:
021-52413122
电子邮件:
hrchen@mail.sic.ac.cn
个人主页:
邮政编码:
200050
通讯地址:
上海市定西路1295号2#706室

简历:

  陈航榕:女,博士,研究员,博士生导师;高性能陶瓷和超微结构国家重点实验室副主任。20017月毕业于中国科学院上海硅酸盐研究所获博士学位;2012年国家杰出青年科学基金获得者,2015年荣获政府特殊津贴。主要从事纳米介孔结构材料、纳米生物材料、纳米催化材料等研究;作为负责人先后主持承担了包括国家863973、国家科技支撑计划、国家自然科学基金、中科院科技创新团队、上海市基础重点、技术标准专项等科研项目。

  在Adv.Mater., Adv.Func.Mater., ACS NanoBiomaterials,等国际著名期刊上发表SCI学术论文250余篇;参与5部中英文专著章节;他引总计13000余次,h因子62;获得30余项国家发明专利授权。荣获上国家自然科学二等奖1项(2011,排名第二);上海市自然科学一等奖2项(2008,排名第二;2014年,排名第五);上海市标准化优秀技术成果二等奖1项(2011,排名第一);中国材料研究学会技术发明二等奖(2020,排名第一)。入选国家****工程有突出贡献中青年专家2013年度);上海市优秀学术带头人计划(2014年度);中国科学院朱李月华优秀研究生导师(2014年度);科技部创新人才推进计划中青年科技创新领军人才(2014年度);第二批国家万人计划科技创新领军人才(2016);第五届中国科学院十大杰出妇女2017)等多项荣誉与奖励。兼任中国超声医学工程学会超声分子影像学专业委员会常务委员;中国生物医学工程学会生物医学光子学分会副秘书长;中国生物材料学会纳米生物材料分会常务委员等职。

 

  主要研究方向:

(1)无机纳米功能材料

(2)纳米生物材料及其肿瘤诊疗研究

(3)纳米(环境、光电化学)催化材料

 

  主要在研项目(负责人):

1)国家自然科学基金生命学部重点基金“超声介导的程序响应多药递送系统与免疫联合治疗研究” 320300612021,1,12025,12,31

2)国家自然科学基金两岸合作基金基于介孔结构P型半导体光阴极的可控构筑及其C催化还原液体燃料研究” 51961165107, 2019,1,12021,12,31

3)上海市港澳台科技合作项目:新型半导体纳米催化剂的构建及其CO2光电还原研究” 19520761000, 2019,9,12022,8,31

4)上海市科委基础重点项目:“新型铁基纳米材料功能化构建及其结肠癌高效化学动力学治疗与机制研究”,19JC1415600, 2019,11,1-2022,10,31

5)国家自然科学基金项目:“无机纳米粒子/转铁蛋白复合载药体系的设计合成及其针对脑胶质瘤的高效诊疗研究” 517723162018,1,12021,12,31

6)国家自然科学基金国际合作项目:“人工工程肿瘤生物磁铁高效聚集相转变型纳米粒用于肿瘤治疗与超声显像监控”,817201080232018,1,1-2022,12,31(合作单位负责人)

 

5年主要SCI论文发表(均为通讯作者):

2020

(1)Qiuhong Zhang, Qiangbing Guo,* Qian Chen, Xiaoxu Zhao, Stephen J. Pennycook, and Hangrong Chen*Highly Efficient 2D NIR-II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal-Chemodynamic Therapy, Advanced Science, 2020, 7,1902576.

(2)Wenxian Du, Tianzhi Liu, Fengfeng Xue, Yu Chen, Qian Chen, Yu Luo, Xiaojun Cai, Ming Ma, Hangrong Chen*, Confined Nanoparticles Growth within Hollow Mesoporous Nanoreactors for Highly Efficient MRI-guided Photodynamic Therapy,Chemical Engineering Journal, 2020, 379, 122251.

(3)Kaicheng Liang, Zhicong Li, Yu Luo,* Qiuhong Zhang, Fangfang Yin, Leijing Xu, Hangrong Chen,* and Han Wang*, Intelligent Nanocomposites with Intrinsic Blood–Brain-Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma, Small, 2020,1906985.

(4)Kaicheng Liang, Hangrong Chen*, Protein-based nanoplatforms for tumor imaging and therapy, WIREs Nanomedicine & Nanobiotechnology, 2020, 12:e1616, https://doi.org/10.1002/wnan.1616.

(5)Chunlei Peng, Nian Ran, Gang Wan, Wanpeng Zhao, Zhaoyu Kuang, Zheng Lu, Chengjun Sun, Jianjun Liu, Lianzhou Wang,* Hangrong Chen*,Engineering Active Fe Sites on Nickel–Iron Layered Double Hydroxide for Oxygen Evolution via Component Segregation, ChemSusChem,2020,13,811-818.

(6)Xiaojun Cai, Kai Zhang, Xue Xie, Xiandi Zhu, Jin Feng, Zhiming Jin, Hong Zhang, Mei Tian*, Hangrong Chen*, Self-assembly Hollow Manganese Prussian White Nanocapsules Attenuate Tau-related Neuropathology and Cognitive Decline, Biomaterials,2020, 231,119678.

(7)Fengfeng Xue, Jufeng Chen, Hangrong Chen*, Design strategy of optical probes for tumor hypoxia imaging, SCIENCE CHINA Life Sciences, 2020, DOI: 10.1007/s11427-019-1569-4.

(8)Shige Wang, Xueqing Yang, Lingling Zhou, Jinfeng Li, Hangrong Chen*, 2D nanostructures beyond graphene: preparation,biocompatibility and their biodegradation behaviors, J.Mater.Chem.B, 2020, 8, 2974-2989.

(9)Shi-Xiong Chen, Ming Ma, Fengfeng Xue, Shuzhan Shen, Qian Chen, Yichen Kuang, Kaicheng Liang, Xiuli Wang, and Hangrong Chen*, Construction of Microneedle-assisted Co-delivery Platform and its Combining Photodynamic/Immunotherapy, Journal of Controlled Release, 2020,324,218-227.

(10) Wenxian Du, Tianzhi Liu*, Fengfeng Xue, Xiaojun Cai, Qian Chen, Yuanyi Zheng, Hangrong Chen*, Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nano-Enzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy, ACS Applied Materials & Interfaces, 2020,12,19285-19294.

(11)Wanpeng Zhao, Chunlei Peng, Zhaoyu Kuang, Qingming Zhang, Yi Xue, Zhaoxia Li, Xiaoxia Zhou, Hangrong Chen*, Na+-induced in situ Reconstitution of Metal Phosphate Enabling Efficient Electrochemical Water Oxidation in Neutral and Alkaline Media, Chemical Engineering Journal, 2020,398,125537.

(12)Ming Ma, Yimeng Shua,Yaohui Tang*, Hangrong Chen,* Multifaceted application of nanoparticle-based labeling strategies for stem cell therapy, Nano Today, 2020,34,100897.

(13)Yu Luo, Xianping Liu, Kaicheng Liang, Qian Chen, Tianzhi Liu, Bo Yin,* and Hangrong Chen*, Disulfide Bond Reversible Strategy Enables GSH Responsive-Transferrin Nanoparticles for Precise Chemotherapy, Adv. Therap.,2020, 2000064.

(14)Jie Shen, Ming Ma*, Hongbo Zhang, Huizhu Yu, Nanjing Hao, Fengfeng Xue, and Hangrong Chen*Microfluidics-Assisted Surface Tri-Functionalization of Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of TumorACS Applied Materials & Interfaces, 2020, 12, 41, 45838–45849.

(15)Zhaoyu Kuang, Wanpeng Zhao, Chunlei Peng, Qingming Zhang, Yi Xue, Zhaoxia Li, Heliang Yao, Xiaoxia Zhou,* and Hangrong Chen*, Hierarchically Porous SnO2 Coupled Organic Carbon for CO2 Electroreduction, ChemSusChem,2020, https://doi.org/10.1002/cssc.202002099.

(16)Zebin Yang, Yu Luo,* Yanan Hu, Kaicheng Liang, Gao He, Qian Chen, Qigang Wang, Hangrong Chen,* Photothermo-promoted nanocatalysis combined with H2S-mediated respiration inhibition for efficient cancer therapy., Adv. Funct. Mater., 2020,2007991.

(17)Shi-Xiong Chen, Fengfeng Xue*, Yichen Kuang, Siyu Chen, Danli Sheng, and Hangrong Chen*, A self-activating nanovesicle with oxygen-depleting capability for efficient hypoxia-responsive chemo-thermo cancer therapy, Biomaterials, 2020,https://doi.org/10.1016/j.biomaterials.2020.120533

(18)Tianzhi Liu, Qian Wan, Chao Zou,* Mengjie Chen, Gang Wan, Xin Liu, Hangrong Chen*, Stepwise Drug Release from a Nanoplatform under MR-Assisted Focused Ultrasound Stimulation, Chemical Engineering Journal, https://doi.org/10.1016/j.cej.2020.128004

 

2019

(1)Qian Chen, Yu Luo, Wenxian Du, Zhuang Liu, Shengjian Zhang, Jiahui Yang, Heliang Yao, Tianzhi Liu, Ming Ma, Hangrong Chen*, Clearable Theranostic Platform with pH-independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy, ACS Applied Materials & Interfaces,2019,11, 18133-18144.

(2)Tianzhi Liu, Qian Wan, Yu Luo, Mengjie Chen, Chao Zou, Ming Ma, Xin Liu, * and Hangrong Chen*On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics, ACS Applied Materials & Interfaces,2019, 11,16285.

(3)Chenyao Wu, Shige Wang*, Jiulong Zhao, Yiyun Liu, Yuting Zheng, Yu Luo, Changqing Ye, Mingxian Huang, and Hangrong Chen*, Redox reaction and TME-enhanced bio-degradation of Fe2O3@WS2-PVP nanocapsules for augmented nanocatalytic, photothermal and chemotherapy, Adv. Funct. Mater., 2019, 1901722.

(4)Qiuhong Zhang, Jingwen Chen, Jie Shen, Shixiong Chen, Kaicheng Liang, Han Wang, and Hangrong Chen*, Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy, Theranostics, 2019; 9(10): 2779-2790.

(5)Yu Luo, Yan Tang, Tianzhi Liu, Qian Chen, Xiaohan Zhou, Ning Wang, Ming Ma, Yingsheng Cheng, Hangrong Chen*, Engineering graphene oxide with ultrasmall SPIONs and smart released drug for cancer theranostics, Chemical Communications, 2019, 55,1963-1966.

(6)Qiuhong Zhang, Ning Wang, Ming Ma, Yu Luo, and Hangrong Chen*, Transferrin Receptor-Mediated Sequential Intercellular Nanoparticles Relay for Tumor Deep Penetration and Sonodynamic Therapy, Adv. Therap. 2019, 1800152.

(7)Huanan Li, Ming Ma, Jingni Zhang, Wei Hou, Hangrong Chen*, Deping Zeng*, Zhibiao Wang, Ultrasound-enhanced Delivery of Doxorubicin-loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy, ACS Applied Materials & Interfaces,2019, 11, 20341?20349.

(8)Wenxian Du, Tianzhi Liu, Fengfeng Xue, Yu Chen, Qian Chen, Yu Luo, Xiaojun Cai, Ming Ma, Hangrong Chen*, Confined Nanoparticles Growth within Hollow Mesoporous Nanoreactors for Highly Efficient MRI-guided Photodynamic Therapy, Chemical Engineering Journal, 2020, 379, 122251.

(9)Zhao Han, Li Hongcheng, Gu Yongwan, Zheng Tingting, Zhao Depeng, Xia Wenzheng, Zhao Yunkun*, Chen Hangrong*, La2O2CO3-induced phase composition oscillation for La-Cu mixed oxides during repeated catalytic soot combustion, Catalysis Science & Technology, 2019, 9, 5100 – 5110.

(10)Xiaoxia Zhou, Min Wang, Dawei Yan, Qinru Li, and Hangrong Chen*, Synthesis and performance of high efficient diesel oxidation catalyst based on active metal species-modified porous zeolite BEAJournal of Catalysis, 2019,379,138-146.

 

2018

(1)Qiuhong Zhang, Jingwen Chen, Ming Ma, Han Wang* and Hangrong Chen*, A Bioenvironment-responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor-homing for Oxygen Enhanced Radiotherapy, Chemistry of Materials, 2018, 30, 5412-5421.

(2) Gang Wan, Xiao-Min Lin, Jianguo Wen, Wanpeng Zhao, Linyu Pan, Jun Tian, Tao Li, Hangrong Chen*, and Jianlin Shi*, Tuning the Performance of Single-Atom Electrocatalysts: Support-Induced Structural Reconstruction, Chemistry of Materials, 2018, 30(21),7494.

(3)Luodan Yu, Yu Chen,* Han Lin, Shanshan Gao, Hangrong Chen* and Jianlin Shi, Magnesium-Engineered Silica Framework for pH-Accelerated Biodegradation and DNAzyme-Triggered Chemotherapy, Small,2018, 14,1800708.

(4)Yu Luodan; Chen Yu;* Lin Han; Du Wenxian; Chen Hangrong;* Shi Jianlin, Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery. Biomaterials 2018, 161, 292-305.

(5)Wanpeng Zhao, Gang Wan, Chunlei Peng, Huaping Sheng, Jianguo Wen, Hangrong Chen*, Key SingleAtom Electrocatalysis in Metal-Organic Framework (MOF)-Derived Bifunctional Catalysts, ChemSusChem, 2018, 11(19),3473-3479.

(6)G. Wan, P. Yu, H. Chen*, J. Wen, C-J Sun, H. Zhou, N. Zhang, Q. Li, W. Zhao, B. Xie, T. Li*, and J. Shi*, Engineering Single-Atom Cobalt Catalysts toward Improved Electrocatalysis, Small 2018, 14, 1704319-1704325.

(7)Jiulong Zhao, Pei Xie, Changqing Ye, Chenyao Wu, Wencheng Han, Mingxian Huang, Shige Wang*, Hangrong Chen*, Chemical Engineering Journal351 (2018) 157168.

(8)Jiulong Zhao, Xiaojun Cai*, Wei Gao, Linlin Zhang, Duowu Zou, Yuanyi Zheng, Zhaoshen Li*, Hangrong Chen*, Prussian Blue Nanozyme with Multi-enzyme Activity Reduces Colitis in Mice, ACS Applied Materials & Interfaces, 2018,10,26108.

(9)Minghua Yao, Ming Ma,* Hongbo Zhang, Yuezhou Zhang, Gang Wan, Jie Shen, Hangrong Chen,* and Rong Wu*, Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cells, Adv. Funct. Mater. 2018, 1804497.

 

2017年以前代表性论文

(1)Tianzhi Liu, Nan Zhang, Zhigang Wang, Meiying Wu, Yu Chen, Ming Ma, Hangrong Chen*,and Jianlin Shi*, Endogenous Catalytic Generation of O2 Bubbles for In Situ Ultrasound-Guided High Intensity Focused Ultrasound Ablation, ACS Nano,2017, 11, 9093?9102.

(2)G. Wan, C. Yang, W. Zhao, Q. Li, N. Wang, T. Li, H. Zhou, H. Chen*, J. Shi*, AnionRegulated Selective Generation of Cobalt Sites in Carbon: Toward Superior Bifunctional Electrocatalysis, Adv. Mater. 2017,29, 1703436-1703443.

(3)Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi and Hangrong Chen*, A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy, Theranostics, 2017; 7(6): 1531-1542.

(4)Ming Ma, Yanhong Yan, Chao Qi, Shengcai Qi, Shixiong Chern, Guangwei Shang, Raorao Wang*, Hangrong Chen* Symmetry-breaking assembled porous calcite microspheres and their multiple dental applicationsSci China Mater2017,60:516-528.

(5)Xiaoxia Zhou, Yu Chen, Tongguang Ge, Zile Hua, Hangrong Chen*, Jianlin ShiSodium carbonate-assisted synthesis of hierarchically porous single-crystalline nanosized zeolitesScience Bulletin2017,62(14),1018-1024.

(6)Xiaojun Cai, Wei Gao, Linlin Zhang, Ming Ma, Tianzhi Liu, Wenxian Du, Yuanyi Zheng, Hangrong Chen*, and Jianlin Shi, Enabling Prussian Blue with Tunable Localized Surface Plasmon Resonances: Simultaneously Enhanced Dual-Mode Imaging and Tumor Photothermal Therapy, ACS Nano, 2016, 10,11115-11126. 

(7)Kun Zhang, Huixiong Xu, Xiaoqing Jia, Yu Chen, Ming Ma, Liping Sun, and Hangrong Chen*, Ultrasound-Triggered Nitric Oxide Release Platform Based on Energy Transformation for Targeted Inhibition of Pancreatic Tumor, ACS Nano, 2016, 10,10816-10828. 

(8)Zhou, XX; Chen, LS; Wan, G; Chen, Y; Kong, QL; Chen, HR*; Shi, JL*, Low Pt-Loaded Mesoporous Sodium Germanate as a High-Performance Electrocatalyst for the Oxygen Reduction Reaction, ChemSusChem, 2016,9(17), 2337-2342.

(9) Mou, J; Lin, TQ; Huang, FQ; Chen, HR* ; Shi, JL*, Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDTBiomaterials, 2016,84,13-24.

(10)Yu, LD; Chen, Y*; Wu, MY; Cai, XJ; Yao, HL; Zhang, LL; Chen, HR*; Shi, JL*"Manganese Extraction" Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of NanoparticlesJ.Am.Chem.Soc., 2016, 138(31), 9881-9894. 

(11)Zhang, K; Li, P; He, YP; Bo, XW; Li, XL; Li, DD; Chen, HR*; Xu, HX*, Synergistic Retention Strategy of RGD Active Targeting and Radiofrequency-enhanced Permeability for Intensified RF&Chemotherapy Synergistic Tumor Treatment, Biomaterials, 2016,99,34-46.

(12) Ma, MYan, F; Yao, MHWei, ZJ; Zhou, DL; Yao, HL; Zheng, HR*; Chen, HR*, Shi, JL, Template-Free Synthesis of Hollow/Porous Organosilica-Fe3O4 Hybrid Nanocapsules toward Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound TherapyACS Applied Materials Interfaces, 2016,8(44),29986-29996.

(13) Wan, G; Ma, M; Jia, A; Chen, LS; Chen, Y; Cui, XZ; Chen, HR*; Shi, JL, 3D hierarchical assembly of optimized heterogeneous carbon nanosheets for highly efficient electrocatalysis, J. Mater. Chem. A, 2016, 4(30), 11625-11629.

(14) Shige Wang, Xiang Li, Yu Chen, Xiaojun Cai, Heliang Yao, Wei Gao, Yuanyi Zheng, Xiao An*, Jianlin Shi and Hangrong Chen*, A Facile One-Pot Synthesis of a Two-Dimensional MoS2/Bi2S3 Composite Theranostic Nanosystem for Multi-Modality Tumor Imaging and Therapy. Advanced Materials. 2015, 27(17),2775

(15) Wang SG, Li K, Chen Y, Chen HR*, Ma M, Feng JW, Jianlin Shi* et al. Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor. Biomaterials. 2015;39:206-17.

(16) Cai XJ, Jia XQ, Gao W, Zhang K, Ma M, Wang SG, Zheng YY, Shi JL*, Chen HR*, A Versatile Nanotheranostic Agent for Efficient Dual-Mode Imaging Guided Synergistic Chemo-Thermal Tumor Therapy. Advanced Functional Materials, 2015, 25172520-2529. 

(17)Mou J, Li P, Liu C, Xu H, Song L, Wang J, Chen HR*, Jianlin Shi*et al. Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy. Small. 2015,11(19),2275-2283. 

(18)Ma M, Huang Y, Chen HR*, Jia XQ, Wang SG, Wang ZZ, Jianlin Shi* et al. Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. Biomaterials. 2015;37:447-55.

(19) Jin Wang, Jinzhen Zhu, Xiaoxia Zhou, Yanyan Du, Weimin Huang, Jianjun Liu*, Wenqing Zhang, Jianlin Shi and Hangrong Chen*, Nanoflower-like weak crystallization manganese oxide for efficient removal of low-concentration NO at room temperature, Journal of Material Chemistry A, 2015, 3(14),7631-7638. 

(20)Xiaoxia Zhou, Hangrong Chen,* Guobin Zhang, Jin Wang, Zhiguo Xie, Zile Hua, Lingxia Zhang and Jianlin Shi*, Cu/Mn co-loaded hierarchically porous zeolite beta:a highly efficient synergetic catalyst for soot oxidation, Journal of Material Chemistry A, 2015, 3(18),9745-9753. 

(21)J.Mou, C.Liu,P.Li, Y.Chen, H.Xu, C.Wei, L.Song*, J.Shi, H.Chen*, A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging, Biomaterials, 2015,57,12-21.

(22)Cai XJ, et al., A Prussian blue-based Core-shell Hollow-structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-responsive Longitudinal Relaxivity, Adv.Mater.2015,27(41), 6382 

(23)Zhang K, et al.,CO2 bubbling-based ‘Nanobomb’ System for TargetedlySuppressing Panc-1 Pancreatic Tumor via Low IntensityUltrasound-activated Inertial Cavitation, Theranostics, 2015, 5 (11), 1291

(24)Shige Wang, Yu Chen,* Xiang Li, Wei Gao, Linlin Zhang, Jun Liu, Yuanyi Zheng ,Hangrong Chen,* and Jianlin Shi, Injectable 2D MoS2 -Integrated Drug Delivering Implantfor Highly Effi cient NIR-Triggered Synergistic TumorHyperthermia,Adv.Mater.2015,27,7117–7122.

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