个人简历：

　　翟万银，副研究员 

　　课题组名称：天然生物材料  

　　教育经历： 

　　2005—2011，中国科学院上海微系统与信息技术研究所，微电子与固体电子专业，博士学位 

　　1999—2002，华东师范大学，生物化学与分子生物学专业，硕士学位 

　　1994-1997，安徽师范大学，生物教育专业，学士学位 

　　工作经历： 

　　2002—至今，中国科学院上海硅酸盐研究所，生物材料与组织工程研究中心，副研究员 

　　曾获得奖励、荣誉称号： 

　　2013年上海市科普教育创新奖（个人）奖（科技部备案） 

　　科研工作简介： 

　　主要研究方向：（1）心血管生物材料和（2）生物材料钙化、血管化促进/抑制研究。 

　　主持完成科研项目：国家自然基金面上“多酚对瓣膜弹性蛋白的交联及其在原位组织工程瓣膜支架制备中的应用研究”、“复合天然交联剂对动物心脏瓣膜交联作用的研究”、“天然交联剂原花青素对动物心脏瓣膜交联作用的研究”，国家863 “新型纳米药物载体靶向控释技术及其细胞生物学效应研究”子课题，上海市自然基金 “用猪主动脉瓣及人骨髓干细胞构建人心脏瓣膜”；作为主要完成人完成：中国科学院创新项目“骨髓基质干细胞构建人心脏瓣膜”等。 

　　科研成果： 

　　发表论文：  

1. Xiaoya Wang Wanyin Zhai(Corresponding Author), Chengtie Wu, Jiamin Zhang, Xiaoning Sun, Hongfeng Zhang, Ziyan Zhu, Jiang Chang. Procyanidins-crosslinked Aortic Elastin Scaffolds with Distinctive Anti-calcification and Biological Properties. Acta Biomaterialia 2015,16(4):81-93.. 
2. Wanyin Zhai, Hongxia Zhanga, Jiamin Zhang, Xiaoning Sun, Hongfeng Zhang, Ziyan Zhu, Jiang Chang. Crosslinking saphenous vein ECM scaffold by procyanidins for in situ tissue engineering of small diameter blood vessel. J Biomed Mater Res Part B: Appl Biomater. 2014, 102(6):1190-8. 
3. Wanyin Zhai, Hongxu Lu, Lei Chen, Xiaoting Lin, Yan Huang, Kerong Dai, Kawazoe Naoki, Guoping Chen, Jiang Chang. Stimulatory effects of the ionic products from Ca-Mg-Si bioceramics on both osteogenesis and angiogenesis in vitro. Acta Biomaterialia 2013, 9(8):8004–14. 
4. Wanyin Zhai, Hongxu Lu, Lei Chen, Xiaoting Lin, Yan Huang, Kerong Dai, Kawazoe Naoki, Guoping Chen, Jiang Chang. Silicate bioceramics induce angiogenesis during bone regeneration. Acta Biomaterialia 2012,8 (1): 341–9. 
5. Wanyin Zhai, Changliang He, Lei Wu, Yue Zhou, Hangrong Chen, Jiang Chang, Hongfeng Zhang. Degradation of hollow mesoporous silica nanoparticles (HMSNs) in human umbilical vein endothelial cells. J Biomed Mater Res Part B: Appl Biomater. 2012;100(5):1397-403. 
6. Wanyin Zhai, Chun-ping Jia, Hui Zhao, Yuan-sen Xu. Procyanidins Inhibit Tumor Angiogenesis by Crosslinking Extracellular Matrix. Chin J Cancer Res 2011,23(2): 99-106. 
7. Xiqin Lü, Wanyin Zhai (co-First author), Yanling Zhou, Yue Zhou, Hongfeng Zhang, Jiang Chang. Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering, J. Mater Sci:Mater Med. 2010,21(2):473–480. 
8. Wanyin Zhai, Xiqin Lu, Jiang Chang, Yanlin Zhou, Hongfeng Zhang. Quercetin crosslinked porcine heart valve matrix: mechanical property, stability, anti-calcification and cytocompatibility. Acta Biomaterialia. 2009,6(2):389–395. 
9. Wanyin Zhai, Jiang Chang, Xiqin Lu. Procyanidins crosslinked heart valve matrix: Anti-calcification effect. J Biomed Mater Res Part B: Appl Biomater 2009, 90B(2):913–921. 
10. Zhai WY，Chang J，Lin KL，Wang JY，Zhao Q，Sun XN，Crosslinking of decellularized porcine heart valve matrix by procyanidins，Biomaterials，2006,27(19):3684-3690. 
11. Wanyin Zhai, Jiang Chang, Hongxu Lu, Guoping Chen. Silicate bioceramics induce angiogenesis during bone regeneration. The 13^th International Symposium on Eco-materials Processing and Design. 2012,1. Guilin, China. Abstract, S5-01-I. p163.(Guest Oral) 
12. Wanyin Zhai, Chenping Jia，Yuansen Xu. Enhanced antitumor activity of Irinotecan combined with gambogic acid on NSCLC. 21st IUBMB and 12st FAOBMB International Congress of Biochemistry and Molecular Biology, August 2-7, 2009, Shanghai, China. Abstract, D-3-017. p158. (ISTP) 
13. Hongxia Zhang, Wanyin Zhai(Corresponding Author), Hongfeng Zhang. A general decellularization method for preparing vascular scaffolds from blood vessels of different diameter and wall-thickness. J East Chin Norm Univ (Natural Science). 2012, (4): 50-60. 
14. 翟万银，吴蕾，贾春平，邵建波，徐元森. 肿瘤微血管芯片的制备及其应用. 功能材料与器件学报, 2011,17(5): 505-12. 
15. 翟万银，周双雯，贾春平，徐元森. 藤黄酸抗肿瘤细胞生物学机制, 细胞生物学杂志, 2009, 31(4): 481-5. 

　　已申请、已批准、已转化的专利 

1. “一种戊二醛与原花青素共交联的人工生物瓣瓣膜的制备方法”.中国专利申请号：201310571743.X。 
2. “一种生物源人工小口径血管及其制备方法”.中国专利批准号：ZL201110165428.8。(该专利已被上海利康生物工程有限公司买断) 
3. “一种可再细胞化的人工生物心脏瓣膜”.中国专利批准号：ZL00910194839.2。 
4. “采用槲皮素交联制备人工生物心脏瓣膜材料的方法”.中国专利批准号：ZL200810033498.6。 
5. “具有生物活性的人工生物瓣瓣膜的制备方法”.中国专利批准号：ZL200510110957.2。