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姓 名:
吴成铁
性    别:
专家类别:
研究员;青年千人;百人;上海优秀学科带头人;浦江人才
学 历:
工学博士
电 话:
021-52412249
传 真:
021-52412249
电子邮件:
chengtiewu@mail.sic.ac.cn
个人主页:
邮政编码:
200050
通讯地址:
上海市长宁区定西路1295号

简历:

吴成铁博士生导师、中央组织部青年千人计划、中科院百人计划、德国洪堡学者、上海市优秀学科带头人和上海市浦江人才计划获得者,科技部863重点项目负责人。澳大利亚昆士兰科技大学客座教授、中国医师协会骨科再生医学工作组副主席、中国生物材料学会生物陶瓷分会秘书长、中国生物医学工程学会组织工程与再生医学分会常务委员、中国生物医学工程协会青年工作委员会委员、中国生物材料学会会员、中国生物医学工程协会会员。学术期刊Applied Materials Today Biomedical Glasses副主编,Acta Biomaterialia” “Progress in Natural Science: Materials International”, “Bioactive Materials等杂志编委;澳大利亚国立健康医学研究司(NHMRC)项目评审专家。2006年初博士毕业于中科院上海硅酸盐研究所后,先后在澳大利亚悉尼大学、昆士兰科技大学及德国德累斯顿工业大学从事研究工作6年。主要从事3D打印生物活性材料用于组织修复材料的研究。2011年底获得中国科学院上海硅酸盐研究所海外杰出人才(中科院百人计划)引进,应聘回国从事科研工作,并获得中组部千人计划(青年项目)。在国外先后主持并完成了瑞士“International Team for Implantology (ITI) Foundation”、德国洪堡委员会、澳大利亚ARC、悉尼大学及昆士兰科技大学等资助的科研项目。并获得德国洪堡研究员、澳大利亚ARC研究员(APDI)、悉尼大学研究员及昆士兰科技大学研究员等四个荣誉研究员(Fellowship)。主编CRC英文专著《Advanced bioactive inorganic materials for bone regeneration and drug delivery》一部,并参与撰写6本英文专著的章节。在生物材料相关领域发表SCI 期刊论文160多篇,主要包括Mater TodayACS NanoAdv Funct Mater 4篇), Biomaterials20篇),Adv Science NPG Asia MaterJ Control Release, Acta Biomater (30)等。论文共被SCI引用6000余次,h指数45。共申请专利24项,获5项中国专利及2项美国专利(PCT)授权,其中2项中国专利与1项美国专利已经转让公司。荣获2015中国生物材料学会优秀青年科学家奖,2015英国皇家化学会Journal of Materials Chemistry Lectureship,2017年中国硅酸盐学会青年科技奖等

 

研究领域:

3D打印等先进制备技术构建新型组织工程支架

生物活性陶瓷及纳米介孔生物活性玻璃用于骨、皮肤组织工程、药物/蛋白传输与肿瘤治疗

生物活性材料与组织细胞(成骨、牙周、牙髓细胞及内皮细胞)的相互作用关系(免疫成骨、成血管化)

热烈欢迎对生物材料研究有兴趣的学生报考研究生

 

目前主持的项目:

国家自然基金中德国际合作重点项目

科技部863重点项目

中组部青年千人计划项目

国家自然基金面上项目

上海市优秀学科带头人项目

上海市生物医药处重点项目

上海市材料基因组计划项目

中科院前沿局优秀青年拔尖人才项目

 

参与的项目:

科技部十三五生物材料基因组计划

国家自然基金重大项目

高性能陶瓷及超微结构国家重点实验室开放课题

 

主持结题的项目:

国家自然基金面上项目

国家自然基金青年项目

上海市浦江人才计划项目

上海市自然基金面上项目

中国科学院-昆士兰州联合项目

中国科学院人才创新项目

中科院上海硅酸盐研究所创新重点培养项目

 

所获奖励:

1.     2017年上海市青年五四奖;

2.     2017 中国硅酸盐学会青年科技奖;

3.     2016年上海长宁区十大杰出青年奖;

4.     2016年中科院上海分院杰出青年奖;

5.     2016年中国生物材料学会优秀青年科学家奖;

6.     2015年上海市优秀学科带头人计划奖;

7.     2015年英国皇家化学会Journal of Materials Chemistry Lectureship奖;

8.     2015年上海市优秀归侨奖;

9.     2013年上海市科技系统青年五四奖;

10. 2012年中央组织部青年千人计划;

11. 2012年中国科学院百人计划;

12. 2012年上海市浦江人才计划;

13. 2011年德国洪堡学者;

14. 2009年澳大利亚研究司ARC-APDI博士后奖学金;

15. 2009年澳大利亚昆士兰科技大学校长博士后Fellowship

16. 2007年澳大利亚悉尼大学校长博士后Fellowship

 

近来发表的代表性专著与期刊论文:

专著

1.       Chengtie Wu, Jiang Chang, Yin Xiao. “Advanced bioactive inorganic materials for bone regeneration and drug delivery" Publisher. CRC Press and Taylor & Francis. (2013).

2.       Chengtie Wu, Yin Xiao. “Mesoporous bioglass/silk composite scaffolds for bone tissue engineering”. In Book: “Biomaterials” ISBN 978-953-307-418-4, by editors: Rosario Pignatello. Publishers: Intech, Croatia 2011, P269-286.

3.       Chengtie Wu, Jiang Chang, Hala Zreiqat. “Engineered Ca-Si based ceramics for skeletal tissue reconstruction”. In Book: “Biomaterials for Bone Regenerative Medicine” by editors: N. Sooraj Hussain and J. D. Santos. Publishers: Trans Tech Publishers (Ttp), Switzerland, 2010. P121-150.

4.       Yongxiang Luo, Chengtie Wu, Jiang Chang*. “Inorganic nanomaterials for bone tissue engineering” In BookBiomedical Nanomaterials”by editors: Youqing Shen and Liangyu Zhao, Wiley 2015.

5.       Mengchao Shi, Jiang Chang*, Chengtie Wu*. “Biomedical glasses: advancing from micro to nano and its potential application.” In Book:  Bioglasses: from bone regeneration to cancer treatment”, by editors: Juliana Marchi, Springer-Verlag, 2016.

6.       Chengtie Wu*, Jiang Chang*. “Strontium-containing mesoporous bioactive glass for regeneration of osteoporotic bone and periodontal tissue.” In BookBio-Nanoceramics for Healthcare Applications”, by editor: Jie Huang, Imperial College Press, 2016.

7.       Chengtie Wu*, Jiang Chang, Yin Xiao. “Bioactive Scaffolds with Multifunctional Properties for Hard Tissue Regenerations.” In Book “Biomaterials for Implants and Scaffolds,” by editor: Qing Li, Yiu-Wing Mai, Springer Series in Biomaterials Science and Engineering, 2016

8.       Zetao Chen, Chengtie Wu, Yin Xiao. “Convergence of osteoimmunology and immunomodulation for the development and assessment of bone biomaterials.” In Book: 'The Immune Response to Implanted Materials and Devices', by editor Bruna Corradetti, Springer-Verlag, 2017.

9.       Hongshi Ma, Jiang Chang, Chengtie Wu. “3D Printing of Calcium Phosphate Bio-scaffolds for Bone Therapy and Regeneration” In Book: “Developments and Applications of Calcine Phosphate Bone Cements” by editor: Changsheng Liu, Hongyan He, Springer Series in Biomaterials Science and Engineering, 2017.

 

代表性期刊论文发表 *通讯作者)

1.       Xiaocheng Wang, Fang lv, Tian Li, YiMing Han, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu*. Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing. ACS Nano 11:11337-11349 (2017)

2.       Cuijun Deng#, Qingqiang Yao#, Chun Feng, Jiayi Li, Liming Wang*, Guofeng Cheng, Mengchao Shi,  Lei Chen, Jiang Chang, Chengtie Wu*. 3D Printing of Bi-lineage Constructive Biomaterials for Bone and Cartilage Regeneration. Advanced Functional Materials 27:1703117-1703130 (2017)

3.       Bo Li, Fukang Yuan, Guanjie He, Xiaoyu Han, Xin Wang, Jinbao Qin, Zheng Xiao Guo, Xinwu Lu,* Qian Wang, Ivan P. Parkin, Chengtie Wu*. Ultrasmall CuCo2S4 nanocrystals: All-in-One Theragnosis Nanoplatform with Magnetic Resonance/Near-Infrared Imaging for Efficiently Photothermal Therapy of Tumors. Advanced Functional Materials 27:1606218-227 (2017)

4.       Hongshi Ma, Chuan Jiang, Dong Zhai, Yongxiang Luo, Yu Chen, Fang Lv, Zhengfang Yi, Yuan Deng, Jinwu Wang, Jiang Chang,* Chengtie Wu*. A bifunctional biomaterial with photothermal effect for tumor therapy and bone regeneration. Advanced Functional Materials 26:1197-1208 (2016)

5.       Yan Wu, Shouan Zhu, Chengtie Wu*, Ping Lu, Changchang Hu, Si Xiong, Jiang Chang, Boon Chin Heng, Yin Xiao, Hong Wei Ouyang*. A bi-lineage conducive scaffold for osteochondral defect regeneration. Advanced Functional Materials 24(28):4473-4483 (2014).

6.       Zetao Chen, Travis Klein, Rachael Z Murray, Ross Crawford, Jiang Chang, Chengtie Wu*, Yin Xiao*. Osteoimmunomodulation for the development of advanced bone biomaterials. Materials Today 19(6):304-321 (2016)

7.       Chun Feng, Wenjie Zhang, Cuijun Deng, Guanglong Li, Jiang Chang, Zhiyuan Zhang, Xinquan Jiang*, Chengtie Wu*. 3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration. Advanced Science 4:1700401 (2017)

8.       Cuijun Deng, Huiying Zhu, Jiayi Li, Chun Feng, Qingqiang Yao, Liming Wang, Jiang Chang, Chengtie Wu*. Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface. Theranostics 8(7):1940-1955 (2018)

9.       Xiaocheng Wang#, Tao Li#, Hongshi Ma, Dong Zhai, Chuan Jiang, Jiang Chang,* Jinwu Wang,* Chengtie Wu*. A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration. NPG Asia Materials 9:376-389 (2017)

10.    Wentao Dang, Tao Li, Bo Li, Hongshi Ma, Dong Zhai, Xiaocheng Wang, Jiang Chang, Yin Xiao, Jinwu Wang*, Chengtie Wu*. A bifunctional scaffold with CuFeSe2 nanocrystals for tumor therapy and bone reconstruction. Biomaterials 160:92-106 (2018)

11.    Mengchao Shi#, Lunguo Xia#, Zetao Chen, Fang Lv, Huiying Zhu, Fei Wei, Shengwei Han, Jiang Chang, Yin Xiao*, Chengtie Wu*. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent. Biomaterials 144:176-187 (2017)

12.    Wenjie Zhang,# Chun Feng,# Guangzheng Yang,# Guanglong Li, Xun Ding, Shaoyi Wang, Yuandong Dou, Zhiyuan Zhang, Jiang Chang, Chengtie Wu*, Xinquan Jiang.* 3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration. Biomaterials 135:85-95 (2017)

13.    Hongshi Ma#, Jian Luo#, Zhe Sun, Lunguo Xia, Mengchao Shi, Mingyao Liu, Jiang Chang, Chengtie Wu*. 3D Printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration. Biomaterials 111:138-148 (2016)

14.    Chengtie Wu, #* Zetao Chen#, Qianju Wu, Deliang Yi, Thor Friis, Xuebin Zheng, Jiang Chang*, Xinquan Jiang*, Yin Xiao*. Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration. Biomaterials 71:35-47 (2015)

15.    Zetao Chen, Jones Yuen, Ross Crawford, Jiang Chang, Chengtie Wu*, Yin Xiao*. The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate. Biomaterials 61: 126-138 (2015).

16.    Zetao Chen, Chengtie Wu*, Wenyi Gu, Travis Klein, Ross Crawford, Yin Xiao*. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials 35(5):1507-18 (2014).

17.            Chengtie Wu#, Yinghong Zhou#, Mengchi Xu, Pingping Han, Lei Chen, Jiang Chang*, Yin Xiao*. Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials 34(2):422-433 (2013).

18.            Chengtie Wu*, Yinghong Zhou, Wei Fan, Pingping Han, Jiang Chang, Jones Yuen, Meili Zhang, Yin Xiao*. Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials 33(7):2076-2085 (2012)

19.    Pingping Han, Chengtie Wu*, Jiang Chang, Yin Xiao*. The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/β-catenin signalling pathway by Li+ ions released from bioactive scaffolds. Biomaterials 33(27):6370-6379 (2012)

20.    Chengtie Wu*, Richard Miron, Anton Sculean, Stefan Kaskel, Thomas Doert, Renate Schulze, Yufeng Zhang*. Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. Biomaterials 32(29):7068-78 (2011)

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