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姓 名:
陈雨
性    别:
专家类别:
研究员,优青,国家万人计划青年拔尖人才,上海市优秀学术带头人
学 历:
博士
电 话:
021-52412018
传 真:
021-52413903
电子邮件:
chenyu@mail.sic.ac.cn
个人主页:
邮政编码:
200050
通讯地址:
上海市定西路1295号

简历:

科研工作简介:

陈雨的主要研究工作围绕生物医用微/纳功能材料的可控制备、生物学效应及其在生物医学中的应用,包括超声诊疗、磁共振/光声/CT造影剂、药物靶向输运、基因治疗、心脏修复、脑神经疾病、组织工程、肿瘤诊疗等,发展了多种新型的制备方法获得了具有临床应用前景的生物材料体系,并发展了多种高效的肿瘤治疗模式(光热、光动力学、磁热、声动力学、放疗增敏、催化医学、免疫治疗、协同治疗等)。

陈雨共发表论文140余篇,包括Nature Communications, Nature Chemical Biology, Chem. Soc. Rev.2篇), Acc. Chem. Res., Adv. Mater.20篇), J. Am. Chem. Soc.4篇), Angew. Chem. Int. Ed., Nano Letters, Adv. Funct. Mater.5篇), ACS Nano7篇), Nano Today, NPG Asia Mater., Small4篇), Biomaterials18篇), Materials Horizons等,第一和通讯作者论文中影响因子大于10的论文36篇。论文被引用8000余次,H-index4711篇论文被Chem. Soc. Rev., Adv. Mater., Adv. Funct. Mater等期刊选为封面或内插画文章发表,10篇论文入选ESI高引用论文(Highly Cited Paper),获得授权国家发明专利6项。 

 

曾获得奖励、荣誉称号:

(1)     国家自然科学基金优秀青年基金获得者

(2)     国家万人计划青年拔尖人才

(3)     国家重点研发计划“青年科学家”专项负责人

(4)     上海市优秀学术带头人

(5)     上海市自然科学一等奖(4/5

(6)      上海市青年科技启明星

(7)     上海市青年拔尖人才

(8)     上海市人才发展基金

(9)     上海市青少年科技创新市长奖

(10) 中国化学会青年人才托举工程

(11) 中国科学院卢嘉锡青年人才奖

(12) 中国科学院优秀博士学位论文

(13) 中国科学院院长特别奖

(14) 上海市长宁区十佳青年创新个人

(15) 中国科学院上海分院青年五四奖章

(16) 上海市科教系统青年五四奖章

(17) 上海市优秀毕业生

(18) 中科院上海硅酸盐研究所青年才俊奖优秀个人奖优秀共产党员 

 

学术兼职:

1)中国超声医学工程学会超声分子影像学专业委员会常务委员

2)中国医药生物技术协会纳米生物技术分会第二届委员会委员

3)中国科学院青年联合会委员

4)中国科学院青年创新促进会会员

5)《MaterialsTodayChemistryEditorial Board Member

6)《ChineseChemicalLetters》青年编委

 

主持的科研项目(>1500万):

(1)      国家自然科学基金优秀青年基金

(2)      国家重点研发计划“纳米专项”青年科学家项目

(3)      国家万人计划青年拔尖人才

(4)      上海市优秀学术带头人

(5)      国家自然科学基金面上项目

(6)      国家自然科学基金青年基金

(7)      中国科学院卓越青年科学家项目

(8)      中国化学会青年人才托举工程项目

(9)      上海市青年科技启明星(A类)项目

(10)   上海市自然科学基金青年基金

(11)   上海市青年拔尖人才项目

(12)   上海市人才发展基金项目

(13)   中国科学院青年创新促进会资助

(14)   中国科学院上海硅酸盐研究所所百人计划项目

(15)   国家重点实验室主任青年基金项目

(16)   中国科学院上海硅酸盐研究所所创新项目

(17)   中科院卢嘉锡青年人才奖配套所创新项目

 

科研成果:

1】出版专著和章节

(1)     Yu Chen, Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems, Springer Press, ISBN 978-3-662-48622-1. (Springer Theses)

(2)     Yu Chen, Ming Ma, Hangrong Chen and Jianlin Shi, Multifunctional Hollow Mesoporous Silica Nanoparticles for MR/US Imaging-Guided Tumor Therapy, Advances in Nanotheranostics, Volume 7, pp. 189-222, Springer Press.

(3)     Yu Chen, Shengjian Zhang, Chapter 15, Mesoporous Silica-BasedHybrid Nanosystems forMagnetic Resonance Imaging-Based Cancer Theranostics, Hybrid Nanomaterials: Design, Synthesis, and Biomedical Applications, pp. 393-414, CRC Press.

(4)     Qianjun He, Yu Chen and Jianlin Shi, Chapter 10: Biomedical applications and biological effects of mesoporous silica nanoparticles, Chemistry of Nanoporous Materials (pp. 324-355). China: Science Press.

(5)     陈雨、陈航榕,第十章第一节:聚焦超声治疗增效剂,《超声分子影像》,pp595-609,科学出版社

 

【2】    代表性学术论文(2010-2018

2018年

(101) Han Lin, Yu Chen* and JianlinShi,*Nanoparticle-Triggered In-Situ Catalytic Chemical Reactions for Tumour-Specific Therapy, Chemical Society Reviews, 2018, 47, 1938-1958.

(100) Bowen Yang, Junhui Yin, Yu Chen,* Shanshan Pan,Heliang Yao, Youshui Gao,* Jianlin Shi,* D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma, Advanced Materials, 2018, 30, 1705611.

(99) Han, Lin, Youwei Wang, Shanshan Gao, Yu Chen* and JianlinShi,*Theranostic 2D Tantalum Carbide (MXene), Advanced Materials, 2018, 30, 1703284.

(98) Zhenli Li, Han Zhang, Jun Han, Yu Chen,*Han Lin and Tian Yang,*. Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma, Advanced Materials, 2018, DOI: 10.1002/adma.201706981.

(97) Luodan Yu, Ping Hu* and Yu Chen,*Advanced Materials, 2018, In press.

(96) Bowen Yang, Yu Chen* and JianlinShi,*Advanced Materials, 2018, In press.

(95) Zhenli Li, Jun Han, LuodanYu,*Xiaoqin Qian, Hao Xing, Han Lin, Mengchao Wu, Tian Yang,* and Yu Chen,*. Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous NanosonosensitizersAdvanced Functional Materials, 2018, DOI: 10.1002/adfm.201800145.

(94) Liang Zhang, Dong Wang,*Ke Yang,Danli Sheng, Bin Tan,Zhigang Wang,Haitao Ran,Hengjing Yi,Yixin Zhong, Han Lin andYu Chen,* Advanced Science, 2018, DOI: 10.1002/advs.201800049.

(93) Han Lin, Yu Chen* and JianlinShi,*Advanced Science, 2018, In press.

(92) Xiaoxia Han, Ju Huang, XiangxiangJing,* Dayan Yang, Han Lin, Zhigang Wang, Pan Li* and Yu Chen,* Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow, ACS Nano, 2018, 12(5), 4545-4555.

(91) Piao Zhu, Yu Chen* and JianlinShi,*Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation, ACS Nano, 2018, 12(4), 3780-3795.

(90) Bowen Yang, Yu Chen,* and Jianlin Shi,* Material Chemistry of Two-Dimensional Inorganic Nanosheets in Cancer Theranostics, Chem, 2018, DOI: 10.1016/j.chempr.2018.02.012.

(89) Luodan Yu, Yu Chen,*Hangrong Chen,* et al. Small, 2018, In press.

(88) Zhuang Liu, ShengjianZhang,* Han Lin, Menglong Zhao, Heliang Yao, Linlin Zhang, Weijun Peng* and Yu Chen,* Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation, Biomaterials, 2018, 155, 54-63.

(87) Liying Wang, Minfeng Huo, Yu Chen,* and Jianlin Shi,* Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy, Biomaterials, 2018, 163, 1-13.

(86) Bowen Yang, Han Lin, Chen Dai, Yu Chen,* and Jianlin Shi,* “Stepwise Extraction” strategy-based injectable bioresponsive composite implant for cancer theranostics, Biomaterials, 2018, 166, 38-51.

(85) Liang Zhang, Danli Sheng, Dong Wang,*Yuanzhi Yao, Ke Yang, Zhigang Wang, Liming Deng and Yu Chen,*?Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance ,Imaging-Guided Efficient Photothermal Ablation of Cancer, Theranostics, 2018, 8(6):1591-1606.

(84) Zhuang Liu, Han Lin, Menglong Zhao, Chen Dai, ShengjianZhang,*Weijun Peng,* and Yu Chen,* 2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics, Theranostics, 2018, 8(6):1648-1664.

(83) Yang Cao, Yuli Chen, Tao Yu, Yuan Guo, Fengqiu Liu, Yuanzhi Yao, Pan Li, Dong Wang, Zhigang Wang, Yu Chen,* and Haitao Ran,* Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound, Theranositcs, 2018, 8(5), 1327-1339.

(82) Lying Wang, Minfeng Huo, Yu Chen,* and Jianlin Shi,*Tumor Microenvironment-Enabled Nanotherapy, Advanced Healthcare Materials, 2018, DOI: 10.1002/adhm.201701156.

(81) Xiaoxia Han, Ju Huang, Han Lin, Zhiang Wang, Pan Li,* and Yu Chen,* 2D Ultrathin MXene-Based Drug-Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer, Advanced Healthcare Materials, 2018, DOI: 10.1002/adhm.201701394.

(80) Bowen Yang, Yu Chen* and Jianlin Shi,*Advanced Healthcare Materials, 2018, In press.

(79) Hailin Tang, Yuan Gao, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran* and Yu Chen,*In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy, ACS Applied Materials and Interface, 2018, 10(18), 15428-15441.

(78) Bowen Yang, Yu Chen,* and Jianlin Shi,* Nanozymes in Catalytic Cancer Theranostics, Progress in Biochemistry and Biophysics, 2018, 45(2), 238-255.

(77) LuyanZong, HuixiaWu,* Han Lin and Yu Chen,* A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics, Nano Research, 2018, DOI: 10.1007/s12274-018-2002-3.

(76) Zhenli Li, Luodan Yu, Tian Yang* and Yu Chen,* Theranostic Nanomedicine by Surface Nanopore Engineering, Science China Chemistry, 2018, In press.

(75) Zhuang Liu, Menglong Zhao, Han Lin, Chen Dai, Caiyue Ren, ShengjianZhang,*Weijun Peng* and Yu Chen,* 2D magnetic titanium carbide MXene for cancer theranostics, Journal of Materials Chemistry B, 2018, 6, 3541-3548.

 

 

2017

(74) Minfeng Huo, Liying Wang, Yu Chen* andJianlin Shi,* Tumor-selective catalytic nanomedicine by nanocatalyst delivery,Nature Communications, 2017, 8, 357.

(73) Haiming Jiang, Rong Deng, Xiuyan Yang, Jialin Shang, Shaoyong Lu, Yanlong Zhao, Kun Song, Xinyi Liu, Qiufen Zhang, Yu Chen, Y Eugene Chinn, Geng Wu, Jian Li, Guoqiang Chen, Jianxiu Yu and Jian Zhang, Nature Chemical Biology, 2017, DOI: 10.1038/nchembio.2442

(72) Ping Huang, Xiaoqin Qian, Yu Chen,* Luodan Yu, Han Lin, Liying Wang, Yufang Zhu,* and Jianlin Shi,* Metalloporphyrin-encapsulated Biodegradable Nanosystems for Highly Efficient MRI-Guided Sonodynamic Cancer Therapy, Journal of the American Chemical Society, 2017, 139(3), 1275–1284.

(71) Han Lin, Xingang Wang, Luodan Yu, Yu Chen,* and Jianlin Shi,*Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion, Nano Letters, 2017, 2017, 17 (1), 384–391.

(70) Hailin Tang, Yuanyi Zheng,* and Yu Chen,* Materials Chemistry of Nanoultrasonic Biomedicine, Advanced Materials, 2017, 20(10), 1604105.

(69) Chen, Dai, Shengjian Zhang,* Zhuang Liu, Rong Wu* and Yu Chen,* Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication, ACS Nano, 2017, DOI: 10.1021/acsnano.7b05215.

(68) Ping Huang, Yu Chen,* Han Lin, Luodan Yu, Linlin Zhang, Liying Wang, Yufang Zhu* and Jianlin Shi,* Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality, Biomaterials, 2017, 125, 23-37.

(67) Lijun Sun, Dangge Wang, Yu Chen,* Liying Wang, Ping Huang, Yaping Li,* Ziwei Liu, Heliang Yao and Jianlin Shi,*Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer, Biomaterials, 2017, 133, 219-228.

(66) Xiaoqin Qian, Xiaoxia Han and Yu Chen,* Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranostics, Biomaterials, 2017, 142, 13-30.

(65) Xiaoqin Qian, Zi Gu* and Yu Chen,* Two-dimensional black phosphorus nanosheets for theranostic nanomedicine, Materials Horizons, 2017, 4, 800-816.

(64) Yang Zhou, Xiaoxia Han, Xiangxiang Jing* and Yu Chen,*Construction of Silica-Based Micro/Nanoplatforms for Ultrasound Theranostic Biomedicine, Advanced Healthcare Materials, 2017, DOI: 10.1002/adhm.201700646.

(63) Liying Wang, Minfeng Huo, Yu Chen* and Jianlin Shi, Advanced Healthcare Materials, 2017, In press.

(62) Lu Yang, Juan Cheng, Yulin Chen, Shengjie Yu., Fengqiu Liu, Yang Sun, Yu Chen* and Haitao Ran,* Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer, Scientific Reports, 2017, doi:10.1038/srep45213.

(61) Yang Zhou, Xiangxiang Jing* and Yu Chen,*Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine, Journal of Materials Chemistry B, 2017, 5, 6451-6470. (Invited Review)

(60) Luodan Yu, Yu Chen* and Hangrong Chen,*H2O2-responsive theranostic nanomedicine, Chinese Chemical Letters, 2017, DOI: 10.1016/j.cclet.2017.05.023. (Invited Review)

(59) Guiju Tao, Zhengyuan Bai, Yu Chen,* Heliang Yao, Meiying Wu, Ping Huang, Luodan Yu, Jiamin Zhang, Chen Dai and Long Zhang,* Generic synthesis and versatile applications of molecularlyorganic–inorganic hybrid mesoporous organosilicananoparticles with asymmetric Janus topologies andstructures, Nano Research, 2017, DOI: 10.1007/s12274-017-1592-5.

(58) Tianzhi Liu, Nan Zhang, Zhigang Wang, Meiying Wu, Yu Chen, Ming Ma, Hangrong Chen, and Jianlin Shi, Endogenous Catalytic Generation of O2 Bubbles for In Situ Ultrasound-Guided High Intensity Focused Ultrasound Ablation, ACS Nano, 2017, DOI: 10.1021/acsnano.7b03772.

(57) Ronghui Wang, Yang Zhou, Ping Zhang, Yu Chen, Wei Gao, Jinshun Xu, Hangrong Chen, Xiaojun Cai, Kun Zhang, Pan Li, Zhigang Wang, Bing Hu, Tao Ying, Yuanyi Zheng, Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization, Theranostics, 2017, 7(4), 846.

 

2016

(56) Luodan Yu, Yu Chen,* Meiying Wu, Xiaojun Cai, Heliang Yao, Linlin Zhang, Hangrong Chen* and Jianlin Shi,* “Manganese Extraction” Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles,Journal of the American Chemical Society, 2016, 138(31), 9881-9894.

(55) Yu Chen* and Jianlin Shi*, Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Framework, Advanced Materials, 2016, 28, 3235-3272.

(54) Xiaoqin Qian, Yuanyi Zheng* and Yu Chen,* Micro/nanoparticle-augmented sonodynamic therapy: breaking the depth shallow of photoactivation, Advanced Materials, 2016, 28(37), 8097-8129.

(53) Meiying Wu, Qingshuo, Meng, Yu Chen,* Lingxia Zhang, Mengli Li, Xiaojun Cai, Yaping Li,* Pengcheng Yu, Linlin Zhang and Jianlin Shi,* Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy, Advanced Materials, 2016, 28, 1963-1969.

(52) Yu Chen,* Lianzhou Wang and Jianlin Shi, Two-dimensional Nano-carbonaceous Materials-enabled Efficient Photothermal Cancer Therapy, Nano Today, 2016, 11(3), 292-308.

(51) Yang Zhou, Yu Chen,* Yuanyi Zheng,* et al, Magnetic Nanoparticle-Promoted Droplet Vaporization for In Vivo Stimuli-Responsive Cancer Theranostics, NPG Asia Materials, 2016, 8, e313; doi:10.1038/am.2016.146.

(50) Minfeng Huo, Yu Chen* and Jianlin Shi,* Triggered-release drug delivery nanosystems for cancer therapy by intravenous injection: where are we now?, Expert Opinion on Drug Delivery, 2016, 13(9), 1195-1198.

(49) Jinshun Xu, Yu Chen,* Liming Deng, Jianxin Liu, Yang Cao, Pan Li, Haitao Ran, Yuanyi Zheng* and Zhigang Wang,*Microwave-Activated Nanodroplet Vaporization for Highly Efficient Tumor Ablation with Real-time Monitoring Performance, Biomaterials, 2016, 106, 264-275.

(48) Kai Zhu, Meiying Wu, H. Lai, C. Guo, Jun Li, Yulin Wang, Yu Chen,* Chunsheng Wang,* Jianlin Shi,* Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair,Biomaterials, 2016, 74, 188-199.

(47) Yufeng You, Zhigang Wang, Haitao Ran, Yuanyi Zheng, Dong Wang, Jinshun Xu, Zhibiao Wang, Yu Chen* and Pan Li,* Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy, Nanoscale, 2016, 8, 4324-4339.

(46) Shige Wang, Jiulong Zhao, Fei Hu, Xiang Li, Xiao An,* Shilin Zhou, Yu Chen,* and Mingxian Huang,* Phase-changeable and bubble-releasing implants for highly efficient HIFU-responsive tumor surgery and chemotherapy,Journal of Materials Chemistry B, 2016,4, 7368-7378.

(45) Hongshi Ma, Chuan Jiang, Dong Zhai, Yongxiang Luo, Yu Chen, Fang Lv, Zhengfang Yi, Yuan Deng, Jinwu Wang, Jiang Chang, Chengtie Wu, A bifunctional biomaterial with photothermal effect for tumor therapy and bone regeneration, Advanced Functional Materials, 26(8), 1197-1208.

(44) Xiaoxia Zhou, Lisong Chen, Gang Wan, Yu Chen, Qinglu Kong, Hangrong Chen, Jianlin Shi, Low PtLoaded Mesoporous Sodium Germanate as a HighPerformance Electrocatalyst for the Oxygen Reduction Reaction, ChemSusChem, 9(17), 2337-2342.

 

2015

(43) Yu Chen, Chaoliang Tan, Hua Zhang* and Lianzhou Wang,* Two-dimensional graphene analogues for biomedical applications, Chemical Society Reviews, 2015, 44, 2681-2701.

(42) Shige Wang, Yu Chen,* X. Li, W. Gao, L. Zhang, J. Liu, Y. Zheng, Hangrong Chen,* Jianlin Shi, Injectable 2D MoS2Integrated Drug Delivering Implant for Highly Efficient NIRTriggered Synergistic Tumor Hyperthermia, Advanced Materials, 2015, 27, 7117-7122.

(41) Meiying Wu, Qingshuo Meng, Yu Chen,* Yanyan Du, Lingxia Zhang, Yaping Li,* Linlin Zhang, Jianlin Shi,* Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery, Advanced Materials, 2015, 27, 215-222.

(40) Yu Chen, Hangrong Chen* and Jianlin Shi,*Nanobiotechnology Promotes Noninvasive High-Intensity Focused Ultrasound Cancer Surgery, Advanced Healthcare Materials, 2015, 4, 158-165.

(39) Yu Chen* and Jianlin Shi,* Mesoporous Carbon Biomaterials, SCIENCE CHINA Materials, 2015, 58, 241-257.

(38) Shengjian Zhang, Xiaoqin Qian, Linlin Zhang, Weijun Peng,* Yu Chen,* Composition–property relationships in multifunctional hollow mesoporous carbon nanosystems for PH-responsive magnetic resonance imaging and on-demand drug release, Nanoscale, 2015, 7, 7632-7643.

(37) Shige Wang, Kai Li, Yu Chen, Hangrong Chen, Ming Ma, Jingwei Feng, Qinghua Zhao, Jianlin Shi, Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor, Biomaterials, 2015, 39, 206-217.

(36) Juan Mou, Pei Li, Chengbo Liu, Huixiong Xu, Liang Song, Jin Wang, Kun Zhang, Yu Chen, Jianlin Shi, Hangrong Chen, Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic ImagingGuided Photothermal Therapy, Small, 2015, 11(19), 2275-2283.

(35) Shige Wang, Xiang Li, Yu Chen, Xiaojun Cai, Heliang Yao, Wei Gao, Yuanyi Zheng, Xiao An, Jianlin Shi, Hangrong Chen, A Facile OnePot Synthesis of a TwoDimensional MoS2/Bi2S3 Composite Theranostic Nanosystem for MultiModality Tumor Imaging and Therapy, Advanced Materials, 2015, 27(17), 2775-2782.

 

2014

(34) Yu Chen, Hangrong Chen and Jianlin Shi, Construction of Homogenous/Heterogeneous Hollow Mesoporous Silica Nanostructures by Silica-Etching Chemistry: Principles, Synthesis and Applications, Accounts of Chemical Research, 2014, 47, 125-137.

(33) Yu Chen, Qingshuo Meng, Meiying, Wu, Shige Wang, Pengfei Xu, Hangrong Chen, Yaping Li, Lingxia Zhang, Lianzhou Wang and Jianlin Shi, Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine, Journal of the American Chemical Society, 2014, 136, 16326-16334.

(32) Yu Chen, Pengfei Xu, Meiying Wu, Qingshuo Meng, Hangrong Chen, Zhu Shu, Jin Wang, Lingxia Zhang, Yaping Li and Jianlin Shi, Colloidal RBCs-Shaped, Hydrophilic and Hollow Mesoporous Carbon Nanocapsules for Highly Efficient Biomedical Engineering, Advanced Materials, 2014, 26, 4294-4301.

(31) Yu Chen, Ling Jiang, Ronghui Wang, Ming Lu, Qunxia Zhang, Yang Zhou, Zhigang Wang, Guangming Lu, Ping Liang, Haitao Ran, Hangrong Chen and Yuanyi Zheng, Injectable Smart Phase-Transformation Implants for Highly Efficient In Vivo Magnetic-Hyperthermia Regression of Tumors, Advanced Materials, 2014, 26, 7468-7473.

(30) Yu Chen, Delai Ye, Meiying Wu, Hangrong Chen, Linlin Zhang, Jianlin Shi and Lianzhou Wang, Break-up of Two-Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer, Advanced Materials, 2014, 26, 7019-7026.

(29) Yu Chen, Pengfei Xu, Zhu Shu, Meiying Wu, Lianzhou Wang, Shengjian Zhang, Yuanyi Zheng, Hangrong Chen, Jin Wang, Yaping Li and Jianlin Shi, Multifunctional Graphene Oxide-Based Triple Stimuli-Responsive Nanotheranostics, Advanced Functional Materials, 2014, 24(28), 4386-4396.

(28) Yu Chen, Hangrong Chen and Jianlin Shi, Drug Delivery/Imaging Multifunctionality of Mesoporous Silica-Based Composite Nanostructures, Expert Opinion on Drug Delivery, 2014, 11(6), 917-930.

(27) Yu Chen, Hangrong Chen and Jianlin Shi, Inorganic Nanoparticles-Based Drug Co-Delivery Nanosystems to Overcome the Multidrug Resistance of Cancer Cells, Molecular Pharmaceutics, 2014, 11, 2495-2510.

(26) Meiying Wu, Qingshuo Meng, Yu Chen, Pengfei Xu, Shengjian Zhang, Yaping Li, Lingxia Zhang, Min Wang, Heliang Yao, Jianlin Shi, Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH‐Responsive Theranostic Platform, Advanced Functional Materials, 2014, 24(27), 4273-4283.

(25) Xia Wang, Hangrong Chen, Kun Zhang, Ming Ma, Faqi Li, Deping Zeng, Shuguang Zheng, Yu Chen, Lixin Jiang, Huixiong Xu, Jianlin Shi, An Intelligent Nanotheranostic Agent for Targeting, RedoxResponsive Ultrasound Imaging, and ImagingGuided HighIntensity Focused Ultrasound Synergistic Therapy, Small, 2014, 10(7), 1403-1411.

(24) Xuemei Zhang, Yuanyi Zheng, Zhigang Wang, Shuai Huang, Yu Chen, Wei Jiang, Hua Zhang, Mingxia Ding, Qingshu Li, Xiaoqiu Xiao, Xin Luo, Zhibiao Wang, Hongbo Qi, Methotrexate-loaded PLGA nanobubbles for ultrasound imaging and Synergistic Targeted therapy of residual tumor during HIFU ablation, Biomaterials, 2014, 35(19), 5148-5161.

(23) Kun Zhang, Hangrong Chen, Faqi Li, Qi Wang, Shuguang Zheng, Huixiong Xu, Ming Ma, Xiaoqing Jia, Yu Chen, Juan Mou, Xia Wang, Jianlin Shi, A continuous tri-phase transition effect for HIFU-mediated intravenous drug delivery, Biomaterials, 2014, 35(22), 5875-5885.

(22) Ming Hua Yao, Ming Ma, Yu Chen, Xiao-qing Jia, Guang Xu, Hui-xiong Xu, Hang-rong Chen, Rong Wu, Multifunctional Bi2S3/PLGA nanocapsule for combined HIFU/radiation therapy, Biomaterials, 35(28), 8197-8205.

 

2013

(21) Yu Chen, Hangrong Chen and Jianlin Shi, In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles, Advanced Materials, 2013, 25, 3144-3176.

(20) Yu Chen, Pengfei Xu, Hangrong Chen, Yongsheng Li, Wenbo Bu, Zhu Shu, Yaping Li, Jiamin Zhang, Lingxia Zhang, Limin Pan, Xiangzhi Cui, Zile Hua, Jin Wang, Linlin Zhang and Jianlin Shi, Colloidal HPMOs NPs: Silica-Etching Chemistry Tailoring, Topological Transformation and Nano-Biomedical Applications, Advanced Materials, 2013, 2013, 25, 3100-3105.

(19) Yu Chen, Hangrong Chen and Jianlin Shi, Engineering of Hollow Mesoporous Nanoparticles for Biomedical Applications, Advanced Porous Materials, 2013, 1, 36-62.

(18) Yang Zhou, Zhigang Wang, Yu Chen, Hongxia Shen, Zhenchun Luo, Ao Li, Qi Wang, Haitao Ran, Pan Li, Weixiang Song, Zhu Yang, Hangrong Chen, Zhibiao Wang, Guangmin Lu, Yuanyi Zheng, Microbubbles from GasGenerating Perfluorohexane Nanoemulsions for Targeted TemperatureSensitive Ultrasonography and Synergistic HIFU Ablation of Tumors, Advanced Materials, 2013, 25(30), 4123-4130.

(17) Xia Wang, Hangrong Chen, Yuanyi Zheng, Ming Ma, Yu Chen, Kun Zhang, Deping Zeng, Jianlin Shi, Au-nanoparticle coated mesoporous silica nanocapsule-based multifunctional platform for ultrasound mediated imaging, cytoclasis and tumor ablation, Biomaterials, 2013, 34(8), 2057-2068.

 

2013年之前

(16) Yu Chen, Hangrong Chen, Yang Sun, Yuanyi Zheng, Deping Zeng, Faqi Li, Shengjian Zhang, Xia Wang, Kun Zhang, Ming Ma, Qianjun He, Linlin Zhang and Jianlin Shi, Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High Intensity Focused Ultrasound Cancer Surgery, Angewandte Chemie International Edition, 2011, 50(52), 12505-12509.

(15) Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang and Jianlin Shi, Engineering “Inorganic Nanoemulsion/Nanoliposome” by Fluoride-Silica Chemistry for Efficient Delivery/Co-delivery of Hydrophobic Agents, Advanced Functional Materials, 2012, 22(8), 1586-1597.

(14) Limin Pan, Qianjun He, Jianan Liu, Yu Chen, Ming Ma, Linlin Zhang, Jianlin Shi, Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles, Journal of the American Chemical Society, 2012, 134(33), 5722-5725.

(13) Xia Wang, Hangrong Chen, Yu Chen, Ming Ma, Kun Zhang, Faqi Li, Yuanyi Zheng, Deping Zeng, Qi Wang, Jianlin Shi, PerfluorohexaneEncapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU), Advanced Materials, 2012, 24(6), 785-791.

(12) Yu Chen, Hangrong Chen, Shengjian Zhang, Feng Chen, Lingxia Zhang, Jiamin Zhang, Min Zhu, Huixia Wu, Jingwei Feng and Jianlin Shi, Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs, Advanced Functional Materials, 2011, 21(2), 270-278.

(11) Yu Chen, Hangrong Chen, Limin Guo, Qianjun He, Feng Chen, Jian Zhou, Jingwei Feng and Jianlin Shi, Hollow/Rattle-type Mesoporous Nanostructures by a Structural Difference-Based Selective Etching Strategy, ACS Nano, 2010, 4(1), 529-539.

(10) Yu Chen, Hangrong Chen, Deping Zeng, Yunbo Tian, Feng Chen, Jingwei Feng and Jianlin Shi, Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery, ACS Nano, 2010, 4(10), 6001-6013.

(9) Yu Gao,Yu Chen, Xiufeng Ji, Xinyu He, Jianlin Shi and Yaping Li, Controlled Intracellular Release of Doxorubicin in Multidrug Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles, ACS Nano, 2011, 5(12), 9788-9798. (Co-first author)

(8) Yu Chen, Hangrong Chen, Shengjian Zhang, Feng Chen, Shikuan Sun, Qianjun He, Ming Ma, Xia Wang, Huixia Wu, Lingxia Zhang and Jianlin Shi, Structure-Property Relationships in Manganese oxide - Mesoporous Silica Nanoparticles Used for T1-Weighted MRI and Simultaneous Anticancer Drug Delivery, Biomaterials, 2012, 33(7), 2388-2398.

(7) Yu Chen, Qi Yin, Xiufeng Ji, Shengjian Zhang, Hangrong Chen, Yuanyi Zheng, Yang Sun, Haiyun Qu, Zheng Wang, Yaping Li, Xia Wang, Kun Zhang, Linlin Zhang and Jianlin Shi, Manganese Oxide-Based Multifunctionalized Mesoporous Silica Nanoparticles for pH-Responsive MRI, Ultrasonography and Circumvent of MDR in Cancer Cells, Biomaterials, 2012, 33(29), 7126-7137.

(6) Ming Ma, Hangrong Chen, Yu Chen, Xia Wang, Feng Chen, Xiangzhi Cui, Jianlin Shi, Au capped magnetic core/mesoporous silica shell nanoparticles for combined photothermo-/chemo-therapy and multimodal imaging, Biomaterials, 2012, 33(3), 989-998

(5) Yang Sun, Yuanyi Zheng, Haitao Ran, Yang Zhou, Hongxia Shen, Yu Chen, Hangrong Chen, Tianyi M Krupka, Ao Li, Pan Li, Zhibiao Wang, Zhigang Wang, Superparamagnetic PLGA-iron oxide microcapsules for dual-modality US/MR imaging and high intensity focused US breast cancer ablation, Biomaterials, 2012, 33(24), 5854-5864.

(4) Yu Chen, Chen Chu, Yuchuan Zhou, Hangrong Chen, Feng Chen, Qianjun He, Yonglian Zhang, Linlin Zhang and Jianlin Shi, Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting, Small, 2011, 7(20), 2935-2944.

(3) Yu Chen, Hangrong Chen, Ming Ma, Feng Chen, Limin Guo, Lingxia Zhang and Jianlin Shi, Double Mesoporous Silica Shelled Spherical/Ellipsoidal Nanostructures: Synthesis and Hydrophilic/Hydrophobic Anticancer Drug Delivery, Journal of Materials Chemistry, 2011, 21(14), 5290-5298.

(2) Yu Chen, Hangrong Chen, Limin Guo and Jianlin Shi, Magnetic Hollow Mesoporous Silica Nanospheres: Facile Fabrication and Ultrafast Immobilization of Enzymes, Journal of Nanoscience and Nanotechnology, 2011, 11(12), 10844-10848.

(1) Qianjun He, Jiamin Zhang, Jianlin Shi, Ziyan Zhu, Linxia Zhang, Wenbo Bu, Limin Guo, Yu Chen, The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses, Biomaterials, 2010, 31(6), 1085-1092.

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